1190831-15-2Relevant academic research and scientific papers
Synthesis of 4,5-dihydro-3,4,4,5,5-pentasubstituted-N-tosyl-1H-pyrazoles
Truong, Phong,Kennedy, G. Davon,Vasquez, Pedro C.,Baumstark
scheme or table, p. 449 - 452 (2010/03/04)
Addition of methyl- or phenyllithium to 3,4,4,5-tetrasubstituted-4H- pyrazoles (1a-b) smoothly produced the extremely air-sensitive anions of 4,5-dihydro-3,4,4,5,5-pentasubstituted-1H-pyrazoles (2a-c) which were converted to the N-tosylated compounds 3a-c in low to very good yields by reaction with tosyl fluoride. The two-step process is a convenient one-pot route to 4,5-dihydro-N-tosyl-1H-pyrazoles.
