1190875-39-8

Basic information

• Product Name: 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid
• Synonyms: 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid;1-(1-BOC-Piperidino)pyrazole-4-boronic acid;1-(Boc-piperidin-4-yl)-pyrazole-4-boronate;1-(1-Boc-piperidin-4-yl)-pyrazole-4-boronic acid;1-Piperidinecarboxylic acid, 4-(4-borono-1H-pyrazol-1-yl)-, 1-(1,1-dimethylethyl) ester
• CAS NO: 1190875-39-8
• Molecular Formula: C₁₃H₂₂BN₃O₄
• Molecular Weight: 295.14248
• Product Categories: Boron Derivatives, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1190875-39-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 481.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.66±0.10(Predicted)
• CAS DataBase Reference: 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid(1190875-39-8)
• EPA Substance Registry System: 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid(1190875-39-8)

Safety Data

• Hazardous Substances Data: 1190875-39-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1190875-39-8 differently. You can refer to the following data:
1. 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-ylboronic acid is used in the preparation of triazolopyrazine derivatives for treating hyperproliferative disorders.
2. 1-(Boc-piperidin-4-yl)-pyrazole-4-boronate is used in the preparation of triazolopyrazine derivatives for treating hyperproliferative disorders.

Upstream product

• 877399-73-0 tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 121-43-7 Trimethyl borate 
• 7732-18-5 water 
• 61676-62-8 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 877399-50-3 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester 
• 1195-66-0 2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 1428476-86-1 4-(4-{6-amino-5-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester 
• 877399-52-5 crizotinib 

Relevant articles and documents

Preparation method of crizotinib

The invention discloses a preparation method of crizotinib. An intermediate (V) is prepared through boric acid condensation, so that the defects of instable borate serving as a raw material, complexity in operation, low yield and large-scale production difficulty in the prior art are overcome. The preparation method is low in cost, simple and convenient to operate, high in yield, good in optical purity and suitable for large-scale production.