1190991-74-2

Upstream product

• 58861-53-3 4-fluorophenylpyridine 
• 21864-90-4 N-(tert-butyl)benzimidoyl cyanide 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 67-68-5 dimethyl sulfoxide 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 109-04-6 2-bromo-pyridine 
• 1765-93-1 4-fluoroboronic acid 
• 135205-66-2 N?cyanosuccinimide 
• 75-05-8 acetonitrile 
• 140-29-4 phenylacetonitrile 

Relevant academic research and scientific papers

A Pd(ii)/Mg-La mixed oxide catalyst for cyanation of aryl C-H bonds and tandem Suzuki-cyanation reactions

A palladium(ii)/magnesium-lanthanum mixed oxide (Pd(ii)/Mg-La) catalyst is a reusable catalyst for cyanation of aromatic C-H bonds by using the combination of NH4HCO3 and DMSO as the ''CN'' source. Moderate to good yields of aromatic nitriles were obtained. An excellent regioselectivity was achieved using the present protocol. A tandem process involving Suzuki coupling followed by a cyanation reaction was also developed using the heterogeneous (Pd(ii)/Mg-La) catalyst. This cascade process resulted in the formation of aromatic nitrile from simple 2-halopyridine. The catalyst was recovered by centrifugation and reused for three consecutive cycles with nearly consistent activity and selectivity. This journal is

Ni-Catalyzed C-H Cyanation of (Hetero)arenes with 2-Cyanoisothiazolidine 1,1-Dioxide as a Cyanation Reagent

A nickel-catalyzed C-H cyanation reaction of arenes has been developed using 2-cyanoisothiazolidine 1,1-dioxide as an electrophilic cyanation reagent. Many different directing groups can be used in this cyanation to obtain a series of cyanation products with good yields. Adopting this strategy to introduce a cyano group, natural alkaloid menisporphine was successfully synthesized through cyano group conversion that further proved the practicality of this cyanation method.

Rhodium-Catalyzed Direct C-H Bond Cyanation in Ionic Liquids

A Cp?Rh(III)/IL-based direct C-H bond cyanation system was developed for the first time. The system is a mild, efficient, and recyclable method for the synthesis of aryl nitriles. Many different directing groups can be used in this cyanation, and the reaction tolerates a variety of functional groups.

Synthetic method of arylnitrile compounds

The invention belongs to the technical field of synthesis of medical and chemical engineering intermediates, and provides a synthetic method of arylnitrile compounds. A series of the arylnitrile compounds are synthesized through a heating reaction of a 2-phenylpyridine derivative and N-cyan-N-p-methoxyphenyl-p-benzenesulfonamide in a solvent with a manganese salt as a catalyst. The arylnitrile compounds are an important composition part of many drugs and bioactive molecules, have important applications in the fields of organic synthesis and medicinal chemistry, and have a broad market prospect. The method has the advantages of simple steps, easily obtained raw materials, mild reaction conditions, great use values and great social and economic benefits.

Copper-mediated C-H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a cyanating agent

A copper-mediated direct C-H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a safe cyanating agent has been successfully developed by using molecular oxygen as the oxidant. The reaction tolerates a variety of functional groups and provides a facile and efficient method for the synthesis of a wide range of (hetero)aryl nitriles.

α-Iminonitrile: A new cyanating agent for the palladium catalyzed C-H cyanation of arenes

An efficient palladium-catalyzed C-H cyanation reaction of arenes using α-iminonitrile as a new cyanating reagent has been developed. With high regioselectivity and broad substrate scope, this reaction offers monocyanated products in moderate to excellent

Cobalt-catalyzed C-H cyanation of (Hetero)arenes and 6-Arylpurines with N -cyanosuccinimide as a new cyanating agent

A cobalt-catalyzed C-H cyanation reaction of arenes has been developed using N-cyanosuccinimide as a new electrophilic cyanating agent. The reaction proceeds with high selectivity to afford monocyanated products with excellent functional group tolerance. Substrate scope was found to be broad enough to include a wide range of heterocycles including 6-arylpurines.

Cobalt-catalyzed C-H cyanation of arenes and heteroarenes

Carboxylate assistance proved to be the key for the success of efficient cobalt(III)-catalyzed C-H cyanations. Thus, an in situ generated cationic cobalt complex was identified as a versatile catalyst for the site-selective synthesis of various aromatic a

Copper-catalyzed aromatic C-H bond cyanation by C-CN bond cleavage of inert acetonitrile

Cut and paste! A Cu-catalyzed aromatic C-H cyanation with acetonitrile as the nitrile source by C-CN cleavage has been developed (see scheme; TMEDA=N,N,N′,N′-tetramethylethylenediamine). The reaction is catalytic in copper, and it is found that using (Me

Copper-catalyzed cyanation of arenes using benzyl nitrile as a cyanide anion surrogate

The copper-catalyzed cyanation of arenes using benzyl nitrile as a cyanide anion surrogate furnishes aromatic nitriles in moderate to good yields. The cascade process involves a copper-catalyzed aerobic C-H oxidation, a retro-cyanohydrination, and a copper-catalyzed aerobic oxidative C-H functionalization. The Royal Society of Chemistry 2012.