1191415-07-2

Upstream product

• 42867-45-8 (dibromomethylene)triphenylphosphorane 
• 1761-61-1 5-bromosalicyclaldehyde 
• 558-13-4 carbon tetrabromide 

Downstream Products

• 1378942-54-1 5-(4-methoxyphenyl)benzofuran-2-carbonitrile 
• 613-33-2 (4,4'-dimethyl-1,1'-biphenyl) 
• 22772-25-4 5-bromo-2-(4-methylphenyl)benzofuran 
• 7168-54-9 4,4'-diethoxybiphenyl 
• 1374787-42-4 5-bromo-2-(4-ethoxyphenyl)benzofuran 
• 1448817-99-9 5-bromo-2-(4-isopropoxyphenyl)benzofuran 
• 128836-59-9 4,4'-Diisopropoxy-biphenyl 
• 398-23-2 4,4'-difluorobiphenyl 
• 1374787-41-3 5-bromo-2-(4-fluorophenyl)benzofuran 
• 6161-50-8 3,3'-dimethoxybiphenyl 
• 1448818-00-5 5-bromo-2-(3-methoxyphenyl)benzofuran 
• 13141-26-9 5-bromo-2-phenylbenzo[b]furan 
• 92-52-4 biphenyl 
• 84102-69-2 5-bromo-benzofuran-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Palladium-Catalyzed Domino Cyclization/Phosphorylation of gem-Dibromoolefins with P(O)H Compounds: Synthesis of Phosphorylated Heteroaromatics

We presented a palladium-catalyzed domino cyclization/phosphorylation of gem-dibromoolefins, which utilize H-phosphinates and secondary phosphine oxides as the phosphine sources, respectively. A variety of phosphorylated heteroaromatics were obtained in m

Highly Efficient Synthesis of 2-Substituted Benzo[ b ]furan Derivatives from the Cross-Coupling Reactions of 2-Halobenzo[ b ]furans with Organoalane Reagents

A highly efficient and simple route for the synthesis of 2-substituted benzo[ b ]furans has been developed by palladium-catalyzed cross-coupling reaction of 2-halobenzo[ b ]furans with aryl, alkynyl, and alkylaluminum reagents. Various 2-aryl-, 2-alkynyl-, and 2-alkyl-substituted benzo[ b ]furan derivatives can be obtained in 23-97% isolated yields using 2-3 mol% PdCl 2/4-6 mol% XantPhos as the catalyst under mild reaction conditions. The aryls bearing electron-donating or electron-withdrawing groups in 2-halobenzo[ b ]furans gave products in 40-97% isolated yields. In addition, aluminum reagents containing thienyl, furanyl, trimethylsilanyl, and benzyl groups worked efficiently with 2-halobenzo[ b ]furans as well, and three bioactive molecules with 2-substituted benzo[ b ]furan skeleton were synthesized. Furthermore, the broad substrates scope and the typical maintenance of vigorous efficiency on gram scale make this protocol a potentially practical method to synthesize 2-substituted benzo[ b ]furan derivatives. On the basis of the experimental results, a possible catalytic cycle has been proposed.

Intramolecular cross-coupling of gem-dibromoolefins: A mild approach to 2-bromo benzofused heterocycles

Highly useful halogenated benzofurans and benzothiophenes are prepared from readily available gem-dibromoolefins using a mild, ligand-free copper catalyzed cross-coupling procedure.