119204-13-6

Basic information

• Product Name: 1-BENZYL-2-(2-HYDROXYETHYL) PIPERIDINE
• Synonyms: 1-BENZYL-2-(2-HYDROXYETHYL) PIPERIDINE
• CAS NO: 119204-13-6
• Molecular Formula: C₁₄H₂₁NO
• Molecular Weight: 219.32264
• Mol File: 119204-13-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 160 °C(Press: 2 Torr)
• Appearance: /
• Density: 1.039±0.06 g/cm3(Predicted)
• PKA: 15.15±0.10(Predicted)
• CAS DataBase Reference: 1-BENZYL-2-(2-HYDROXYETHYL) PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-2-(2-HYDROXYETHYL) PIPERIDINE(119204-13-6)
• EPA Substance Registry System: 1-BENZYL-2-(2-HYDROXYETHYL) PIPERIDINE(119204-13-6)

Safety Data

• Hazardous Substances Data: 119204-13-6(Hazardous Substances Data)

Usage

Chemical structure

The compound has a piperidine backbone, a benzyl group, and a hydroxyethyl side chain.

Common use

It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds.

Pharmaceutical applications

The compound has potential pharmaceutical applications due to its ability to modulate the activity of neurotransmitters in the central nervous system.

Unique structure

Its unique structure makes it a valuable precursor in the development of medicinal drugs and research chemicals.

Field of application

1-BENZYL-2-(2-HYDROXYETHYL) PIPERIDINE has diverse potential applications in the field of medicinal chemistry and drug development.
It's worth noting that the material provided does not give specific information about the chemical properties of the compound, such as its molecular weight, solubility, or reactivity. Additionally, it does not provide any information about the synthesis methods or the specific pharmaceuticals or organic compounds that are synthesized using this compound as an intermediate.

Upstream product

• 34418-91-2 2,3,4,5-tetrahydropyridine N-oxide 
• 100-39-0 benzyl bromide 
• 106968-19-8 (S)-2 
• 134256-17-0 (R)-2,2-dimethyl-1-phenylpropyl vinyl ether 
• 77034-34-5 ethyl N-benzylpipecolinate 
• 22722-98-1 sodium bis(2-methoxyethoxy)aluminium dihydride 
• 119204-12-5 2-isobutoxyhexahydroisoxazolo<2,3-a>-pyridine 
• 110-89-4 piperidine 
• 98-88-4 benzoyl chloride 
• 119204-19-2 (2S,3aR)-8-Benzyl-2-isobutoxy-hexahydro-isoxazolo[2,3-a]pyridin-8-ium; bromide 
• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 19774-49-3 1-phenyloctahydropyrido[1,2-c][1,3]oxazine 
• 100-44-7 benzyl chloride 

Downstream Products

• 19774-49-3 1-phenyloctahydropyrido[1,2-c][1,3]oxazine 
• 120014-06-4 donepezil 
• 145546-80-1 (E)-2-((1-benzylpiperidine-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one 
• 78944-63-5 C₁₄H₂₁NO₂ 
• 1393836-97-9 2-[1-benzyl-2-((indan-2-yl)(thiazol-2-yl)amino)ethyl]piperidine 
• 1393836-96-8 2-[1-benzyl-2-((indan-2-yl)amino)ethyl]piperidine 
• 1025909-53-8 (1-benzylpiperidin-2-yl)acetaldehyde 
• 136704-11-5 1-benzyl-2-(2-chloroethyl)piperidine hydrochloride 
• 132525-85-0 1-benzyl-4-phenylthiooctahydroazocine 
• 132525-82-7 1-benzyl-4-phenoxyoctahydroazocine 
• 132525-83-8 1-benzyl-2-(2-phenoxyethyl)piperidine 
• 132525-86-1 1-benzyl-2-(2-phenylthioethyl)piperidine 
• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 132525-81-6 O-2-(1-benzyl-2-piperidyl)ethyl O-phenyl thionocarbonate 

Relevant articles and documents

Cycloaddition of 2,3,4,5-Tetrahydropyridine N-Oxide to Vinyl Ethers. Enantioselective Synthesis of 2-(N-Benzylpiperidin-2-yl)ethanol

The title compound has been obtained in high optical purity by cycloaddition of 2,3,4,5-tetrahydropyridine N-oxide and (R)-2,2-dimethyl-1-phenylpropyl vinyl ether followed by N-benzylation and reduction of the salt with lithium aluminium hydride.

USE OF AMINOINDANE COMPOUNDS IN TREATING OVERACTIVE BLADDER AND INTERSTITIAL CYSTITIS

The present application provides methods of using the aminoindane compounds of formula (I) or (II) in treating an overactive bladder or interstitial cystitis by administering one or more of the compounds to a patient.

Electrooxidative cyclization of hydroxyamino compounds possessing a benzyl group

Several novel 2-aryl-1,3-oxazinane and 2-aryl-1,3-oxazolidine derivatives were synthesized from N-benzyl-2-piperidineethanols and N-benzyl-2- piperidinemethanols, respectively, by using electrooxidative methods in methanol. For these reactions, the yields of the corresponding cyclized compounds were significantly increased by using catalytic amounts of iodide ions. In contrast, 3-dialkylamino-1-phenylpropanols afforded the expected cyclic 6-phenyl-1,3-oxazinane derivatives using only a small excess of base. Georg Thieme Verlag Stuttgart · New York.