1192131-77-3Relevant academic research and scientific papers
Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives
Li, Wen-Qun,Wang, Xu-Li,Qian, Keduo,Liu, Ying-Qian,Wang, Chih-Ya,Yang, Liu,Tian, Jin,Morris-Natschke, Susan L.,Zhou, Xing-Wen,Lee, Kuo-Hsiung
, p. 2363 - 2369 (2013/05/21)
Twenty new acyl thiourea derivatives of podophyllotoxin and 4′-demethylepipodophyllotoxin were prepared and screened for their cytotoxicity against four human tumor cell lines, A-549, DU-145, KB, and KBvin. With IC50 values of 0.098-1.13 μM, co
Synthesis and antitumor activity of novel aroylthiourea derivatives of podophyllotoxin
Zhao, Yu,Wang, Chengniu,Wu, Zhonghua,Fang, Jinghuai,Zhu, Li
, p. 17 - 24 (2012/06/01)
A novel series of 4β-[(4-substituted) aroylthiourea] derivatives of podophyllotoxin were synthesized and their abilities to inhibit the growth of cancer cells were investigated by MTT assay. Compound 4a possessed the highest cytotoxicity on HepG2, A549 an
