748151-22-6Relevant academic research and scientific papers
A novel, stereoselective and practical protocol for the synthesis of 4β-aminopodophyllotoxins
Liu, Ying-Qian,Li, Lin-Hai,Yang, Liu,Li, Hong-Yu
, p. 533 - 536 (2010)
Ritter reaction of podophyllotoxins with chloroacetonitrile and subsequent cleavage of the chloroacetyl group in the resulting chloroacetamide with thiourea under both classical heating and ultrasonic conditions is an efficient procedure for the synthesis
Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives
Li, Wen-Qun,Wang, Xu-Li,Qian, Keduo,Liu, Ying-Qian,Wang, Chih-Ya,Yang, Liu,Tian, Jin,Morris-Natschke, Susan L.,Zhou, Xing-Wen,Lee, Kuo-Hsiung
, p. 2363 - 2369 (2013/05/21)
Twenty new acyl thiourea derivatives of podophyllotoxin and 4′-demethylepipodophyllotoxin were prepared and screened for their cytotoxicity against four human tumor cell lines, A-549, DU-145, KB, and KBvin. With IC50 values of 0.098-1.13 μM, co
A novel, stereoselective and practical protocol for the synthesis of 4?2-aminopodophyllotoxins
Liu, Ying-Qian,Li, Lin-Hai,Yang, Liu,Li, Hong-Yu
, p. 533 - 536 (2015/03/05)
Ritter reaction of podophyllotoxins with chloroacetonitrile and subsequent cleavage of the chloroacetyl group in the resulting chloroacetamide with thiourea under both classical heating and ultrasonic conditions is an efficient procedure for the synthesis
Podophyllotoxin derivatives as antitumor agents
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Page/Page column 9, (2010/11/26)
This invention relates to podophyllotoxin derivatives, more particularly to 4β-amino and 4β-amido derivatives of podophyllotoxin and 4′-O-demethylepipodophyllotoxin, which are useful for the treatment of tumors. Processes for the preparation of the compou
