1192805-45-0

Upstream product

• 79-03-8 propionyl chloride 
• 243844-35-1 N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide 
• 127-65-1 chloroamine-T 
• 84904-61-0 o-(1'-butenyl)bromobenzene 

Downstream Products

• 1278540-54-7 C₁₉H₁₆ClNO₃ 
• 1278540-62-7 C₁₉H₁₉NO₂ 
• 1278540-59-2 C₂₆H₂₂ClNO₃ 

Relevant academic research and scientific papers

Tandem Phospha-Michael Addition/N-Acylation/ Intramolecular Wittig Reaction of aza-o-Quinone Methides: Approaches to 2,3-Disubstituted Indoles

A tandem phospha-Michael addition/N-acylation/intramolecular Wittig reaction of in situ formed aza-o-QMs is disclosed. This approach features high functional group tolerance and provides a convenient and practical access to biologically significant indole derivatives (37 examples, up to 91% yield) under mild reaction conditions. (Figure presented.).

Catalytic synthesis method of N-p-toluenesulfonyl-2-substituted indole compound

The invention discloses an N-p Toluenesulfonyl-2-the catalytic synthesis method of substituted indole compound, which includes the following steps: under the condition of normal temp and normal pressure, N-p -Toluenesulfonyl-2-alkynyl-substituted aniline

Synthesis of Functionalized Indoles via Palladium-Catalyzed Aerobic Cycloisomerization of o-Allylanilines Using Organic Redox Cocatalyst

A scalable and practical synthesis of functionalized indoles via Pd-tBuONO cocatalyzed aerobic cycloisomerization of o-allylanilines is reported. Using molecular oxygen as a terminal oxidant, a series of substituted indoles were prepared in moderate to good yields. The avoidance of hazardous oxidants, heavy-metal cocatalysts, and high boiling point solvents such as DMF and DMSO enables this method to be applied in pharmaceutical synthesis. A practical gram-scale synthesis of indomethacin demonstrates its application potential.

A Synthetic Route to 2-Alkyl Indoles via Thiophenol-Mediated Ring-Opening of N-Tosylaziridines Followed by Copper Powder-Mediated C-N Cyclization/Aromatization

A simple strategy for the syntheses of 2-alkyl indoles via regioselective ring-opening of 2-(2-haloaryl)-3-alkyl-N-tosylaziridines with thiophenol, followed by copper powder-mediated intramolecular C-N cyclization and subsequent aromatization by the elimi

Aromatic enamide/ene metathesis toward substituted indoles and its application to the synthesis of indomethacins

A. steric and electronic effect: on enamide/ene metathesis, a novel preparation of 2-substituted indoles and 3-substituted indoles using enamide-ene metathesis as a key reaction, and its application to the synthesis of indoniethacin are described. Wiley-VCH Verlag GmbH & Co. KGaA.