119367-63-4

Basic information

• Product Name: 1,2,4,5-tetrahydro-2-phenyl-3-benzoxepine
• Synonyms: 1,2,4,5-tetrahydro-2-phenyl-3-benzoxepine
• CAS NO: 119367-63-4
• Molecular Weight: 224.302
• Mol File: 119367-63-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,2,4,5-tetrahydro-2-phenyl-3-benzoxepine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4,5-tetrahydro-2-phenyl-3-benzoxepine(119367-63-4)
• EPA Substance Registry System: 1,2,4,5-tetrahydro-2-phenyl-3-benzoxepine(119367-63-4)

Safety Data

• Hazardous Substances Data: 119367-63-4(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 119367-95-2 2-<2-(Benzyloxy)ethyl>benzaldehyde tosylhydrazone 
• 119367-92-9 2-<2-(Benzyloxy)ethyl>benzoic acid 
• 119367-93-0 2-<2-(Benzyloxy)ethyl>benzyl alcohol 
• 119367-94-1 2-<2-(Benzyloxy)ethyl>benzaldehyde 
• 4702-34-5 isochroman-1-one 
• 167170-50-5 2-<2-(2-hydroxyethyl)phenyl>-1-phenylethanol 
• 119367-91-8 C₂₃H₂₃N₂O₃S^(1-)*Na⁽¹⁺⁾ 
• 67-56-1 methanol 

Relevant articles and documents

Lithium 2-(2-lithiomethylphenyl)ethanolate from isochroman: Easy preparation of substituted benzoxepines and functionalised arenes

The reaction of isochroman (1) with an excess of lithium powder and a catalytic amount of DTBB (2.5 mol %) in THF at 20°C yields the title intermediate, which by reaction with different electrophiles (H2O, D2O, CO2 and carbonyl compounds) at temperatures ranging between -78 and 20°C yields, after hydrolysis, the corresponding products 3. Diols 3h-m, derived from benzaldehyde or ketones, give upon treatment with 85% phosphoric acid the corresponding benzoxepines 5h-m. In the other cases, Friedel-Crafts products resulting from a rearrangement of the first carbenium ion formed, are obtained.