167170-50-5

Basic information

• Product Name: 1,2-Benzenediethanol, a-phenyl-
• CAS NO: 167170-50-5
• Molecular Formula: C16H18O2
• Molecular Weight: 242.318
• Mol File: 167170-50-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-Benzenediethanol, a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzenediethanol, a-phenyl-(167170-50-5)
• EPA Substance Registry System: 1,2-Benzenediethanol, a-phenyl-(167170-50-5)

Safety Data

• Hazardous Substances Data: 167170-50-5(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 100-52-7 benzaldehyde 
• 119-61-9 benzophenone 
• 98-86-2 acetophenone 
• 135-02-4 ortho-anisaldehyde 
• 493-05-0 isochromane 

Downstream Products

• 119367-63-4 1,2,4,5-tetrahydro-2-phenyl-3-benzoxepine 

Relevant articles and documents

Lithium 2-(2-lithiomethylphenyl)ethanolate from isochroman: Easy preparation of substituted benzoxepines and functionalised arenes

The reaction of isochroman (1) with an excess of lithium powder and a catalytic amount of DTBB (2.5 mol %) in THF at 20°C yields the title intermediate, which by reaction with different electrophiles (H2O, D2O, CO2 and carbonyl compounds) at temperatures ranging between -78 and 20°C yields, after hydrolysis, the corresponding products 3. Diols 3h-m, derived from benzaldehyde or ketones, give upon treatment with 85% phosphoric acid the corresponding benzoxepines 5h-m. In the other cases, Friedel-Crafts products resulting from a rearrangement of the first carbenium ion formed, are obtained.

Functionalised organotitanium compounds: From lithium to titanium intermediates in chemoselective reactions with carbonyl compounds

The reaction of functionalised organolithium compounds 1 with an equimolecular mixture of two carbonyl compounds in the presence of 2 equiv. of triisopropoxytitanium chloride can discriminate between aldehyde and ketone, the process being selective for al