1194-74-7

Usage

Uses

Used in Pharmaceutical Industry:
4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl(9CI) is utilized as a chemical reagent for the synthesis of pharmaceutically active dimethylpyrimidines. These synthesized compounds hold promise for various therapeutic applications, given their potential to exhibit biological activities beneficial in treating a range of medical conditions. The reagent aids in the development of new drugs by providing a key structural component in the creation of these active pharmaceutical ingredients.

InChI:InChI=1/C6H8N2O2/c1-3-5(9)7-4(2)8-6(3)10/h1-2H3,(H2,7,8,9,10)

Upstream product

• 609-08-5 Diethyl methylmalonate 
• 609-02-9 methyl-malonic acid dimethylester 
• 124-42-5 acetamidine hydrochloride 

Downstream Products

• 1780-33-2 4,6-dichloro-2,5-dimethyl-pyrimidine 
• 18260-92-9 6-chloro-2,5-dimethyl-pyrimidin-4-ylamine 

Relevant academic research and scientific papers

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes

Pyrimidine Derivatives Which Are Antagonists Of Vitronectin Receptor

A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.

Novel vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same

A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.

PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF

The present invention encompasses novel substituted pyrimidine compounds of Formula (I): which act as MCH receptor antagonists. These compounds are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson’s disease, epilepsy, and addiction.

5-substituted-6-aminopyrimidines, composition and uses as cardiotonic agents for increasing cardiac contractility

Herein is disclosed amino-pyrimidine derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for increasing cardiac contractility in a mammal.