1194491-85-4

Upstream product

• 75-75-2 methanesulfonic acid 
• 1194488-55-5 N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]cyclopropanamine 
• 67973-32-4 3,5-dibromo-4-methylbenzoic acid 
• 1229245-22-0 3-bromo-N-cyclopropyl-5-[(1E)-3-methoxyprop-1-en-1-yl]-4-methylbenzamide 
• 1229245-24-2 3,5-dibromo-N-cyclopropyl-4-methylbenzamide 
• 7697-26-9 3-bromo-4-methylbenzoic acid 
• 1229245-19-5 3-bromo-5-(3-methoxyprop-1-yn-1-yl)-4-methylbenzoic acid 
• 1229245-20-8 3-bromo-5-iodo-4-methylbenzoic acid 
• 1229245-21-9 3-bromo-N-cyclopropyl-5-(3-methoxypropyl)-4-methylbenzamide 
• 1229245-18-4 3-bromo-N-cyclopropyl-5-(3-methoxyprop-1-yn-1-yl)-4-methylbenzamide 

Downstream Products

• 1312350-29-0 (3R,4S)-N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]-N-cyclopropyl-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-piperidine-3-carboxamide 
• 1312350-32-5 (3R,4S)-N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]-N-cyclopropyl-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-piperidine-3-carboxamide hydrochloride 
• 1312350-26-7 tert-butyl (3R,4S)-3-{[[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl](cyclopropyl)amino]carbonyl}-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

Convergent kilo-scale synthesis of a potent renin inhibitor for the treatment of hypertension

Process research and development of a synthetic route towards a novel renin inhibitor (1) is described. The highly convergent synthetic route provided 1 in 15% yield on multikilogram scale with a longest linear sequence of 11 steps. The use of catalytic h

3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS

The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.