115289-57-1

Upstream product

• 69555-14-2 ethyl N-diphenylmethylene glycine 
• 106-95-6 allyl bromide 
• 924-44-7 glyoxylic acid ethyl ester 
• 356762-89-5 N-(1,1-diphenyl-3-butenyl)amine 
• 119-61-9 benzophenone 
• 1013-88-3 Benzophenone imine 
• 3060-50-2 2,2-diphenylglycine 
• 946164-43-8 allyl 2,2-diphenylglycinate 
• 946164-41-6 C₂₅H₂₃NO₄ 
• 97611-55-7 ethyl 2-acetoxy-2-diphenylmethyleneaminoacetate 
• 762-72-1 allyl-trimethyl-silane 

Downstream Products

• 171922-32-0 ethyl 2-allyl-N-(diphenylmethylene)-2-propargylglycinate 
• 149117-84-0 ethyl 2-(((benzyloxy)carbonyl)amino)pent-4-enoate 
• 166655-28-3 ethyl (allyl)(isocyano)acetate 
• 31456-25-4 camptothecin 
• 119479-32-2 2-((tert-butyloxycarbonyl)amino)-4-pentenoic acid 
• 213379-65-8 ethyl 2-[(phenylamino)carbonylamino]pent-4-enoate 

Relevant academic research and scientific papers

Easy and efficient generation of reactive anions with free and supported ylides as neutral Bronsted bases

The tris(dimethylamino)-C-dimethylphosphorus ylide 5 and the tris(dimethylamino)phosphorus ylide C-bound to Merrifield's resin 6 are used as strong non-nucleophilic bases in N-alkylation reactions of β-amino phosphine oxides and α-amino acid derivatives,

A practical and efficient synthesis of (±)- camptothecin

A practical and efficient synthesis of (±)-camptothecin from glycine via an intramolecular Michael addition is described.

Catalytic Generation of Rhodium Silylenoid for Alkene-Alkyne-Silylene [2 + 2 + 1] Cycloaddition

An alkene-alkyne-silylene [2 + 2 + 1] cycloaddition takes place in the rhodium-catalyzed reaction of 1,6-enynes with borylsilanes bearing an alkoxy group on the silicon atoms, which react as synthetic equivalents of silylene. The reaction proceeds efficiently in 1,2-dichloroethane at 80-110 °C in the presence of a rhodium catalyst bearing bis(diphenylphosphino)methane (DPPM) as a ligand to afford 1-silacyclopent-2-enes in good to high yields.

Lewis acidic FeCl3 promoted 2-aza-Cope rearrangement to afford α-substituted homoallylamines in dimethyl carbonate

The iron(iii)-catalyzed efficient strategy for the synthesis of α-substituted homoallylamines was accomplished via a cationic 2-aza-Cope rearrangement of aldimines, generated in situ by condensation of commercially available aldehydes and easily synthesizable 1,1-diphenylhomoallylamines. This reaction features a broad substrate scope with high yields and is conducted in an eco-friendly solvent, i.e. dimethyl carbonate.

Arginase Inhibitors and Their Therapeutic Applications

Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a

Iron-catalyzed oxidative C - H/C - H cross-coupling: An efficient route to α-quaternary α-amino acid derivatives

Fully loaded: A coordinating activation strategy has been developed to furnish α-quaternary α-amino acids through the iron(III)-catalyzed oxidative functionalization of α-C(sp3) - H bonds of α-tertiary α-amino acid esters. The reaction exhibits a broad substrate scope for both α-amino acids and nucleophiles (Nu) as well as good functional-group tolerance (see scheme, DTBP=di-tert-butyl peroxide, DCE=1,2-dichloroethane). Copyright

The synthesis and characterization of a pentafluorosulfanylated peptide

The design and synthesis of pentafluorosulfanyl-containing heptad amino acid sequence was described. The three-dimensional conformation of the peptide was investigated by using CYANA (combined assignment and dynamics algorithm for NMR applications) and th

PENTAFLUOROSULFANYL CONTAINING AMINO ACIDS

There are provided SF5-containing amino acids of general formulas (I), (II), (III) and processes for preparing same. Other embodiments are also disclosed.

HCV PROTEASE INHIBITORS

This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.

C-C bond-forming reactions via Pd-mediated decarboxylative α-lmino anion generation

α-lmino anions are generated under neutral reaction conditions via a Pd-mediated decarboxylation of allyl diphenylglycinate imines with concomitant formation of a π-allylpalladium species. The resulting delocalized anion can attack the π-allyl-Pd(ll) spec