1195-33-1Relevant academic research and scientific papers
A General, One-Pot Method for the Synthesis of Sulfinic Acids from Methyl Sulfones
Gauthier, Donald R.,Yoshikawa, Naoki
supporting information, p. 5994 - 5997 (2016/12/09)
A simple and efficient method for converting methyl sulfones to sulfinic acids is described. The process involves alkylation with a benzylic halide, followed by in situ elimination of the resulting styrene in the presence of excess base to yield a sulfinic acid in a single reaction process. The usefulness of the alkylation-elimination sequence is demonstrated by generating a variety of sulfinic acids from methyl sulfones. Late stage functionalization and 14C-labeling of several biologically active methyl sulfones were accessed via sulfinate intermediates.
Kinetics of the Reaction of 2,4-Dinitrophenyl-4'-substituted Phenyl Sulfones with Morpholine in Methanol
El-Mallah, Nabila M.,Hamed, E. A.,El-Bardan, A. A.
, p. 319 - 328 (2007/10/03)
The rates of morpholine-desulfonylation of 2,4-dinitrophenyl-4'-substituted phenylsulfones (1-6: aryl = 4-Y-C6H4, Y = H, CH3, OCH3, Br, Cl and NO2) have been measured in methanol at different temperatures (25 deg C-40 deg C) and the activation parameters were calculated.A good Hammett correlation was obtained with ρ values of 0.43-0.75.The plot ΔH(excit.) versus ΔS(excit.) gave an isokinetic temperature at 339 deg K.
