119540-41-9Relevant academic research and scientific papers
SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists
Gomez, Laurent,Hack, Michael D.,McClure, Kelly,Sehon, Clark,Huang, Liming,Morton, Magda,Li, Lina,Barrett, Terrance D.,Shankley, Nigel,Breitenbucher, J. Guy
, p. 6493 - 6498 (2008/04/02)
A high throughput screening campaign revealed compound 1 as a potent antagonist of the human CCK1 receptor. Here, we report the syntheses and SAR studies of 1,5-diarylpyrazole analogs with various structural modifications of the alkane side cha
Pyrazole CCK1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free-Wilson additivity
McClure, Kelly,Hack, Michael,Huang, Liming,Sehon, Clark,Morton, Magda,Li, Lina,Barrett, Terrance D.,Shankley, Nigel,Breitenbucher, J. Guy
, p. 72 - 76 (2007/10/03)
High throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Evaluation of the CCK1 SAR in a series of these diarylpyrazole antagonists was conducted in a matrix synthesis format revealing additive (Free
