8
LIU ET AL.
nitrobenzaldehyde and acetone. A critical appraisal with a focus
on theory. Chirality. 2018;30(4):445‐456.
extraction temperature of 9.1°C, (S,S)‐DIOP‐Pd concen-
tration of 1.7 mmol/L, and pH of aqueous phase of 7.0.
At this optimal condition, the highest pf was obtained
with value of 0.08996. In addition, the possible recogni-
tion mechanism of (S,S)‐DIOP‐Pd toward 3‐chloro‐
phenylglycine enantiomers was discussed. The interac-
tions between carboxyl and palladium, phenyl groups in
3‐chloro‐phenylglycine and (S,S)‐DIOP, amino and palla-
dium are three important acting forces in chiral
recognition.
9. Straniero V, Casiraghi A, Fumagalli L, Valoti E. How do reac-
tion conditions affect the enantiopure synthesis of 2‐
substituted‐1,4‐benzodioxane
2018;30(7):943‐950.
derivatives?
Chirality.
10. Liu J‐J, Wu G‐H, Tang K‐W, Liu X, Zhang P‐L. Equilibrium of
chiral extraction of 4‐nitro‐D,L‐phenylalanine with BINAP metal
11. Tang K, Fu T, Zhang P. Equilibrium studies on enantioselective
liquid‐liquid extraction of homophenylalanine enantiomers
with
metal‐BINAP
complexes.
Process
Biochem.
ACKNOWLEDGMENTS
2012;47(12):2275‐2283.
12. Tang K, Fu T, Zhang P, Yang C, Zhou C, Liang E. Modeling and
experimental evaluation of enantioselective liquid‐liquid extrac-
tion of (D, L)‐4‐chlorophenylglycine in a biphasic system. Chem
Eng Res des. 2015;94:290‐300.
This work was financially supported by the National Nat-
ural Science Foundation of China (grant no. 51703060)
and the Hunan Provincial Innovation Foundation for
Postgraduate (grant no. CX2018B673).
13. Verkuijl BJV, Minnaard AJ, de Vries JG, Feringa BL. Chiral sep-
aration of underivatized amino acids by reactive extraction with
palladium‐BINAP
complexes.
J
Org
Chem.
ORCID
14. Verkuijl BJV, Schuur B, Minnaard AJ, de Vries JG, Feringa BL.
Chiral separation of substituted phenylalanine analogues using
chiral palladium phosphine complexes with enantioselective
liquid‐liquid extraction. Org Biomol Chem. 2010;8(13):3045‐3054.
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