1196088-61-5Relevant articles and documents
Metal-free synthesis of ortho -CHO diaryl ethers by a three-component sequential coupling
Liu, Fangliang,Yang, Huameng,Hu, Xinquan,Jiang, Gaoxi
supporting information, p. 6408 - 6411 (2015/01/09)
A practical, metal-free, and highly chemoselective approach was developed for the synthesis of ortho-CHO diaryl ethers by a three-component sequential coupling of arynes, N,N-dimethylformamide (DMF), and diaryliodonium salts. Diverse functional groups including halo, nitryl, and bulky substituents and heteroaromatics are well tolerated. Mechanistically, isotopic tracer experiments reveal that the diaryliodonium salt serves as an electrophile to trap the transient intermediates generated from the [2 + 2] cyclization of an aryne and DMF.
Palladium-catalyzed intramolecular C-H arylation of arenes using tosylates and mesylates as electrophiles
Nervig, Christine S.,Waller, Peter J.,Kalyani, Dipannita
supporting information, p. 4838 - 4841,4 (2020/09/16)
This paper describes a method for the palladium catalyzed intramolecular C-H arylation using tosylates and mesylates as electrophiles. The transformation is efficient for the synthesis of various heterocyclic motifs including furans, carbazoles, indoles, and lactams. Additionally, a protocol for the one-pot sequential tosylation/arylation of phenol derivatives is presented.
A new synthetic route to unsymmetrical 9-arylxanthenes
Das, Sajal Kumar,Singh, Ritesh,Panda, Gautam
scheme or table, p. 4757 - 4761 (2010/02/28)
A. facile and general three-step synthetic route towards unsymmetrical 9-arylxanthenes was developed. The reaction sequence involves nucleophilic substitution of commercially available 2-fluorobenzaldehydes with arenoxides, Grignard reaction of the resulting 2-arenoxybenzaldehydes with arylmagnesium bromides, followed by FeCl3-catalyzed intramolecular diarylmethylation of the resulting carbinols, This strategy was extended to access symmetrical as well as unsymmetrical 9-arylthioxanthenes.
