1196507-66-0

Basic information

• Product Name: 4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 4,5-difluoro-;4,5-Difluoro-7-azaindole
• CAS NO: 1196507-66-0
• Molecular Formula: C7H4F2N2
• Molecular Weight: 154.1168664
• EINECS: 200-258-5
• Mol File: 1196507-66-0.mol

Chemical Properties

• Appearance: /
• Density: 1.49
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.44±0.40(Predicted)
• CAS DataBase Reference: 4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine(1196507-66-0)
• EPA Substance Registry System: 4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine(1196507-66-0)

Safety Data

• Hazardous Substances Data: 1196507-66-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine is used as a building block for the synthesis of pharmaceuticals due to its unique chemical properties and potential therapeutic activities. Its antiviral and antitumor capabilities make it a promising candidate for the development of new drugs targeting various diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine is utilized as a key component in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Organometallic Chemistry:
DFP serves as a ligand in organometallic chemistry, playing a crucial role in the formation and stabilization of organometallic complexes. Its presence can influence the reactivity, selectivity, and catalytic properties of these complexes.
Used in Catalysis:
4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine is employed as a catalyst or a catalyst component in various chemical reactions, enhancing the efficiency and selectivity of the processes. Its unique structure and properties allow it to facilitate challenging transformations and improve the overall yield of desired products.

Upstream product

• 640735-25-7 4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine 
• 640735-24-6 4-bromo-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine 
• 348640-06-2 4-bromo-7-azaindole 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 271-63-6 7-Azaindole 
• 685513-89-7 4,5-difluoro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1196507-69-3 4,5-difluoro-1H-pyrrolo[2,3-b]pyridin-3-amine 

Relevant articles and documents

Compound serving as protein kinase inhibitor and application of compound

The invention discloses a compound used as a protein kinase inhibitor and application of the compound, the compound has an obvious inhibition effect on protein kinase activity, can be used as a BTK inhibitor for preparing medicines for treating BTK-mediated diseases such as malignant tumors, autoimmune diseases and the like, and has wide application prospect.

AZAINDOLE CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS

Provided herein are compounds of Formula (I) and Formula (II): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of tuberculosis.

OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.

PYRROLOPYRIDINES AS KINASE INHIBITORS

Compounds of Formula (I) are useful for inhibition of CHKl and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.