1197-26-8

Basic information

• Product Name: PHENYLMETHANETHIOSULFONATE
• Synonyms: PHENYLMETHANETHIOSULFONATE;PH-MTS;S-Phenyl Methanethiosulfonate
• CAS NO: 1197-26-8
• Molecular Formula: C₇H₈O₂S₂
• Molecular Weight: 188.27
• Product Categories: MTS and Sulfhydryl Active Reagents;MTS & Sulfhydryl Active Reagents
• Mol File: 1197-26-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 88.5-90.5°C
• Boiling Point: 315.6°C at 760 mmHg
• Flash Point: 144.7°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 0.000799mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly)
• CAS DataBase Reference: PHENYLMETHANETHIOSULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYLMETHANETHIOSULFONATE(1197-26-8)
• EPA Substance Registry System: PHENYLMETHANETHIOSULFONATE(1197-26-8)

Safety Data

• Hazardous Substances Data: 1197-26-8(Hazardous Substances Data)

Usage

Description

PHENYLMETHANETHIOSULFONATE, also known as PMTS, is a chemical compound that is a crystalline solid. It is known for its specific and rapid reaction with thiols to form mixed disulfides, making it a valuable tool in the study of various biological systems.

Uses

Used in Pharmaceutical Research:
PHENYLMETHANETHIOSULFONATE is used as a probe for [investigating the structures of important biological channels and transporters] because of its ability to react specifically and rapidly with thiols to form mixed disulfides.
Used in the Study of ACh Receptor Channel:
PHENYLMETHANETHIOSULFONATE is used as a structural probe for [the ACh receptor channel] to help researchers understand the mechanisms and structures of this crucial receptor channel in the nervous system.
Used in the Study of GABA Receptor Channel:
PHENYLMETHANETHIOSULFONATE is used as a structural probe for [the GABA receptor channel] to aid in the investigation of the structure and function of this essential receptor channel in the central nervous system.
Used in the Study of Lactose Permease:
PHENYLMETHANETHIOSULFONATE is used as a structural probe for [lactose permease] to gain insights into the transport mechanisms and structural aspects of this important membrane protein involved in lactose transport.

InChI:InChI=1/C7H8O2S2/c1-11(8,9)10-7-5-3-2-4-6-7/h2-6H,1H3

Upstream product

• 14173-25-2 methyl phenyl disulfide 
• 20277-69-4 sodium methansulfinate 
• 931-59-9 benzenesulfenyl chloride 
• 4972-29-6 benzenesulphinyl chloride 
• 873-55-2 sodium benzenesulfonate 
• 6829-66-9 N-butylbenzenesulfinamide 
• 50695-55-1 N-hydroxylmethanesulfonamide 
• 108-98-5 thiophenol 
• 124-63-0 methanesulfonyl chloride 
• 98-09-9 benzenesulfonyl chloride 
• 882-33-7 diphenyldisulfane 
• 14204-24-1 N-(phenylthio)succinimide 
• 67-68-5 dimethyl sulfoxide 
• 624-92-0 Dimethyldisulphide 

Downstream Products

• 1374694-90-2 6-endo-methylsulfonyl-7-syn-phenylsulfanylbicyclo[3.1.1]heptane 
• 1374694-93-5 6-endo-methylsulfonyl-7-anti-phenylsulfanylbicyclo[3.1.1]heptane 

Relevant articles and documents

Direct conversion of sulfinamides to thiosulfonates without the use of additional redox agents under metal-free conditions

Direct conversion of sulfinamides to thiosulfonates is described. Without the use of additional redox agents, the reaction proceeds smoothly in the presence of TFA under metal-free conditions. This protocol possesses many advantages such as odourless and stable starting materials, broad substrate scope, selective synthesis, and mild reaction conditions. This journal is

An iodine-mediated new avenue to sulfonylation employingN-hydroxy aryl sulfonamide as a sulfonylating agent

A novel and highly efficient I2/K2CO3mediated regioselective sulfonylation of thiophenols, aryl acetylenic acid and aromatic alkynes withN-hydroxy sulfonamide has been developed.N-hydroxy sulfonamide has been used for the first time for the synthesis of these sulfones. The scope and versatility of the reaction has been demonstrated by the regio- and stereoselective synthesis of different analogs of sulfones with various structural features.

Disproportionate Coupling Reaction of Sodium Sulfinates Mediated by BF3·OEt2: An Approach to Symmetrical/Unsymmetrical Thiosulfonates

The BF3·OEt2-mediated disproportionate coupling reaction of sodium sulfinates was found for the first time. In this reaction, various S-S(O)2 bonds can be formed, efficiently giving thiosulfonates in moderate to excellent yields. As a convenient protocol for the synthesis of symmetrical and unsymmetrical thiosulfonates, its reaction mechanism involves the formation of a thiyl radical and sulfonyl radical via a sulfinyl radical disproportionation. What is more, this transformation can also be applied practically as a gram-scale reaction and to the two-step synthesis of sulfone and sulfonamide in one pot in situ using thiosulfonate as an intermediate.