119786-13-9Relevant academic research and scientific papers
An efficient chemo-enzymatic approach to the enantioselective synthesis of 2-methyl-1,3-propamedical derivatives
Santaniello, Enzo,Ferraboschi, Patrizia,Grisenti, Paride
, p. 5657 - 5660 (1990)
Lipase-catalyzed transesterification of 2-methyl-1,3-propanediol 1 in chloroform affords enantiomerically pure (S)-(-)-acetate 2, from which the (R)-(+)-silyl ethers 4a-b can be efficiently prepared (>98% ee). The (S)-TBDPS derivative 4b could be also efficiently and enantioselectively prepared by the same enzymatic procedure, starting from racemic 5b.
LIPASE-CATALYZED ASYMMETRIC SYNTHESIS OF CHIRAL 1,3-PROPANEDIOLS AND ITS APPLICATION TO THE PREPARATION OF OPTICALLY PURE BUILDING BLOCK FOR RENIN INHIBITORS
Tsuji, Keiichiro,Terao, Yoshiyashu,Achiwa, Kazuo
, p. 6189 - 6192 (2007/10/02)
Asymmetric synthesis of chiral 2-substituted-1,3-propanediols was realized the lipase-catalyzed transesterification in vinyl acetate and it was applied to the synthesis of an optically active sulfone derivate.
