119816-71-6Relevant articles and documents
Synthesis, antiproliferative and mitochondrial impairment activities of bis-alkyl-amino transplatinum complexes
Dalla Via, Lisa,García-Argáez, Aída N.,Adami, Arianna,Grancara, Silvia,Martinis, Pamela,Toninello, Antonio,Belli Dell'Amico, Daniela,Labella, Luca,Samaritani, Simona
, p. 6965 - 6972 (2013)
A convenient synthetic route and the characterization of complexes trans-[PtCl2(L)(PPh3)] (L = Et2NH (2), (PhCH2)2NH (3), (HOCH2CH2) 2NH) (4) are reported. The antiproliferative activity was evaluated on three human tumor cell lines. The investigation on the mechanism of action highlighted for the most active complex 4 the capacity to affect mitochondrial functions. In particular, both the induction of the mitochondrial permeability transition phenomenon and an aspecific membrane damage occurred, depending on concentration.
Amine attack on coordinated alkenes: An interconversion from anti-Markovnikoff to Markovnikoff products
Pryadun, Ruslan,Sukumaran, Dinesh,Bogadi, Robert,Atwood, Jim D.
, p. 12414 - 12420 (2007/10/03)
A sequence of alkene complexes of platinum, PtCl2(PPh 3)(alkene) (alkene = ethylene, propene, 1-butene, cis-2-butene, 1-hexene, 1-octene, and 1-decene), has been prepared. These complexes are characterized by NMR spectroscopy, including assignment of each proton, and X-ray crystal structures of the 1-propene and 1-hexene complexes. Each complex was reacted with diethylamine. For the 1-hexene, 1-octene, and 1-decene complexes, the amine displaces the alkene. For the smaller alkenes, the diethylamine nucleophilically attacks the coordinated alkene. For propene and 1-butene, the low-temperature addition leads to the anti-Markovnikoff nucleophilic attack, which slowly converts at room temperature to the Markovnikoff product. The transformation from anti-Markovnikoff to Markovnikoff addition occurs without diethylamine dissociation.
