119880-01-2Relevant academic research and scientific papers
Consice Synthesis of CC-1065/Duocarmycin Pharmacophore Using the Intramolecular Heck Reaction
Sakamoto, Takao,Kondo, Yoshinori,Uchiyama, Masanobu,Yamanaka, Hiroshi
, p. 1941 - 1942 (2007/10/02)
3-Methyleneindoline derivatives were synthesized by intramolecular Heck reaction of N-allyl-2-iodoaniline derivatives in the presence of Ag2CO3.This method was successfully applied to the synthesis of the CC-1065/duocarmycin pharmacophore.
Synthesis of N-(phenylsulfonyl)-CI, N-((tert-butyloxy)carbonyl)-CI, CI-CDPI 1, and CI-CDPI 2: CC-1065 functional analogues incorporating the parent 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (CI) left-hand subunit
Boger, Dale L.,Wysocki Jr., Ronald J.,Ishizaki, Takayoshi
, p. 5230 - 5240 (2007/10/02)
Full details of the synthesis of N-(phenylsulfonyl)- and N-((tert-butyloxy)carbonyl)-1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one [N-(phenylsulfonyl)-CI (9) and N-BOC-CI (10)] constituting stable derivatives of the parent cyclopropylcyclohexadienone rin
