119899-86-4

Upstream product

• 119900-89-9 Methyl (S)-4-phosphono-3-(tert-butyldiphenylsiloxy)butyrate 
• 119900-72-0 (S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 119673-71-1 Methyl 3S-((t-butyl)diphenylsilyloxy)-4-bromo butanoate 
• 119673-72-2 (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 88759-56-2 (S)-bromo-3-hydroxybutyric acid methyl ester 
• 119899-89-7 C₂₅H₃₉O₆PSi₂ 
• 119899-81-9 (S)-4-(hydroxymethoxyphosphinyl)-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 119901-67-6 (S)-4-(hydroxymethoxyphosphinyl)-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester dicyclohexylamine salt 
• 119942-64-2 C₂₇H₄₅O₆PSi₃ 

Downstream Products

• 119900-71-9 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[(E)-2-(4'-fluoro-3,5,3'-trimethyl-biphenyl-2-yl)-vinyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 119900-65-1 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[1-(4-fluoro-phenyl)-3-isopropyl-1H-indol-2-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 119900-83-3 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[3-(4-fluoro-phenyl)-1-isopropyl-1H-indol-2-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 129122-73-2 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-({(E)-2-[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-butyric acid methyl ester 
• 129122-52-7 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-({(E)-2-[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-butyric acid methyl ester 
• 129122-44-7 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 129122-71-0 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 137586-66-4 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[6-cyclopropyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 135427-17-7 (E),(S)-4-<<2-<4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinyl>ethenyl>methoxyphosphinyl>-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 137604-58-1 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-({(E)-2-[2-cyclopropyl-4-(4-fluoro-phenyl)-5-methyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-butyric acid methyl ester 

Relevant academic research and scientific papers

Phosphorus-containing HMG-CoA reductase inhibitors

Novel phosphorus-containing compounds which inhibit the activity of HMG-CoA reductase, including a 5-pyrimidinyl-containing moiety. Pharmaceutical compositions and methods of use for the treatment or prevention of hypercholesterolemia, atheroschlerosis, h

Phosphorus-Containing Inhibitors of HMG-CoA Reductase. 2. Synthesis and Biological Activites of a Series of Substituted Pyrydynes Containing a Hydroxyphosphinyl Moiety

A series of 2,3,4,(5),6-substituted pyridines containing a hydroxyphosphinyl functionality have been prepared and were evaluated for their ability to inhibit the enzyme HMG-CoA reductase.Systematic substitution of both R1-R4 and X-Y