41125-77-3

Usage

Uses

Used in Scientific Research:
5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol is used as a fluorescent probe for its ability to emit light upon interaction with specific analytes, which is instrumental in the study of biological and chemical processes.
Used in Analytical Chemistry:
As a sensor, 5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol is utilized for detecting and quantifying various analytes, such as metal ions and biological molecules, due to its sensitivity and selectivity.
Used in Fluorescent Imaging:
5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol is employed as a contrast agent in imaging techniques to visualize cellular and molecular structures within biological samples.
Used in Detection of Enzyme Activity:
5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol serves as a tool for monitoring enzyme activity, providing insights into enzymatic reactions and mechanisms.
Used in Studying Protein-Protein Interactions:
5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol is used to investigate the interactions between proteins, which is crucial for understanding cellular functions and signaling pathways.
Used in Medical Research:
5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol's potential applications in medical research include the development of diagnostic tools and therapeutic agents, capitalizing on its fluorescent and sensing properties to advance healthcare solutions.

Upstream product

• 1199-02-6 5-phenyl-3H-[1,3,4]oxadiazol-2-one 
• 625-58-1 ethyl nitrate 
• 132509-33-2 N-t-butoxycarbonyl-N'-4-nitrobenzaldehyde hydrazone 
• 1422157-58-1 N′-[chloro-(4-nitrophenyl)methylene]-tert-butylcarbazate 
• 555-16-8 4-nitrobenzaldehdye 
• 124-38-9 carbon dioxide 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 122-04-3 4-nitro-benzoyl chloride 
• 4291-13-8 2-(4-nitrophenyl)-1,3,4-oxadiazole 
• 530-62-1 1,1'-carbonyldiimidazole 
• 62-23-7 4-nitro-benzoic acid 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 201230-82-2 carbon monoxide 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 3206-36-8 2-ethoxy-5-(4-nitrophenyl)-1,3,4-oxadiazole 
• 39636-15-2 3-ethyl-5-(4-nitro-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 41125-93-3 2-(4-nitro-phenyl)-5-propoxy-[1,3,4]oxadiazole 
• 41126-10-7 5-(4-nitro-phenyl)-3-propyl-3H-[1,3,4]oxadiazol-2-one 
• 62121-05-5 3-isopropyl-5-(4-nitro-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 41125-94-4 2-isopropoxy-5-(4-nitro-phenyl)-[1,3,4]oxadiazole 
• 129221-14-3 N-(4-Benzyl-2,5-dioxo-imidazolidin-1-yl)-4-nitro-benzamide 
• 121649-32-9 5-(4-Nitro-phenyl)-2-oxo-[1,3,4]oxadiazole-3-carboxylic acid N-phenyl-N'-[1-phenyl-meth-(E)-ylidene]-hydrazide 
• 83725-85-3 N-(2,4-Dioxo-1,4-dihydro-2H-quinazolin-3-yl)-4-nitro-benzamide 
• 85916-60-5 3-Hydroxymethyl-5-(4-nitro-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 861536-01-8 1-(4-amino-benzoyl)-carbonohydrazide 
• 85916-63-8 3-Chloromethyl-5-(4-nitro-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 121649-40-9 N-(3,5-Dioxo-1-phenyl-[1,2,4]triazolidin-4-yl)-4-nitro-benzamide 
• 113118-47-1 5-(4-aminophenyl)-1,3,4-oxadiazol-2(3H)-one 

Relevant academic research and scientific papers

DMF as Methine Source: Copper-Catalyzed Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles

An unprecedented Cu-catalyzed direct annulation of hydrazides with N,N-dimethylformamide (DMF) was developed, providing an efficient synthesis of valuable 1,3,4-oxadiazoles. This process features the short reaction time and can be safely conducted on gram scale. The reaction also facilitated the convenient synthesis of 1,3,4-oxadiazole-2(3H)-ones. Moreover, the mechanistic studies suggest that the source of CH is from the N-methyl group of DMF. (Figure presented.).

Palladium-catalyzed oxidative O-H/N-H carbonylation of hydrazides: Access to substituted 1,3,4-oxadiazole-2(3 H)-ones

A novel palladium-catalyzed oxidative annulation reaction for the C-O, C-N bond formations is developed. The intramolecular cyclocarbonylation provides an efficient and direct approach for the construction of valuable 1,3,4-oxadiazole-2(3H)-ones and their

Synthesis of 5-substituted-3H-[1,3,4]-oxadiazol-2-one derivatives: A carbon dioxide route (CDR)

A carbon dioxide route (CDR) for making biologically important 5-substituted-3H-[1,3,4]-oxadiazol-2-ones (SHOs) has been accomplished through synthesis and cyclization of a variety of hydrazides as the key intermediates. All of these hydrazides were prepared readily in 89-97% yields by reacting acid chlorides with a hydrazine monohydrate in the initial step. Then, SHOs were obtained in high yields from hydrazides by reacting them with carbon dioxide under basic conditions. More notable than the high yields, is that the present CDR process for the first time has succeeded in providing a straightforward cyclization reaction leading to SHO formation with simple reagents in ethanol solution.

Synthesis of 5-aryl-3H-[1,3,4]oxadiazol-2-ones from N′-(chloro-aryl- methylene)-tert-butylcarbazates using basic alumina as an efficient and recyclable surface under solvent-free condition

The synthesis of biologically important 5-aryl-3H-[1,3,4]oxadiazol-2-ones has been carried out by heating the easily synthesized N′-(chloro-aryl- methylene)-tert-butylcarbazates on basic alumina surface under solvent-free condition. The dual characteristic of basic alumina as a solid support as well as a nucleophile is successfully exploited in these reactions. The method provides special attributions such as reduced reaction times, easier work-up procedures, and good to excellent yields as well as increased purity of products and most importantly environmentally friendly protocols. The basic alumina is easily recovered and utilized for further reactions several times without serious loss of activity.

THIAZOLE DERIVATIVES AND USE THEREOF

The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

N-PHENYLPYRIDONE TYPE III PHOSPHODIESTERASES

Phosphodiesterase (type III) inhibitors having the formula: which are useful in stimulating cardiac activity and in treating congestive heart failure and bronchoconstriction, pharmaceutical compositions including these inhibitors, and methods of using these compounds to produce phosphodiesterase (type III) inhibition in mammals

Some 1-Aroyl-4,4-dialkylsemicarbazides and Their Cyclization to Afford 5-Aryl-1,3,4-oxadiazol-2(3H)-ones

Some 1-aroyl-4,4-dialkylsemicarbazides have been prepared by reacting aroyl-hydrazides with dimethyl- or diethyl-carbamoyl chloride.In boiling DMF they lose dimethylamine or diethylamine to give 5-aryl-1,3,4-oxadiazol-2(3H)-ones. - Keywords: 1-Aroyl-4,4-d

Synthesis of Substituted N-(2,4-Dioxo-1,2,3,4-tetrahydroquinazolinyl)benzamides and N-(2-Thiono-4-oxo-1,2,3,4-tetrahydroquinazolinyl)benzamides

Substuted N-(2,3-dioxo-1,2,3,4-tetrahydroquinazolinyl)benzamides (3a-g) and substituted N-(2-thiono-4-oxo-1,2,3,4-tetrahydroquinazolinyl)benzamides (4a-g) were synthetized in one step from the reaction of methyl anthranilate with 2-aryl-1,3,4-oxadiazolin-5-ones (1a-g) and 2-aryl-1,3,4-oxadiazoline-5-thiones (2a-g), respectively, in m-cresol at 150-160 deg C.Alternative routes leading to the formation of 3a and 4a are also reported.