41125-77-3

Basic information

• Product Name: 5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol
• Synonyms: 5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol
• CAS NO: 41125-77-3
• Molecular Formula: C₈H₅N₃O₄
• Molecular Weight: 207.15
• Mol File: 41125-77-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol(41125-77-3)
• EPA Substance Registry System: 5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol(41125-77-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 41125-77-3(Hazardous Substances Data)

Usage

General Description

5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol is an organic compound with the molecular formula C9H6N4O4. It is a yellow crystalline substance that is commonly used as a fluorescent probe in biological and chemical research. 5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol has demonstrated potential for use as a sensor for various analytes, including metal ions and biological molecules. Its unique chemical structure makes it highly suitable for applications in fluorescent imaging and detection, as well as for studying enzyme activity and protein-protein interactions. 5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol has a range of potential uses in scientific and medical research, making it an important compound in the field of chemical and biological sciences.

Upstream product

• 1199-02-6 5-phenyl-3H-[1,3,4]oxadiazol-2-one 
• 625-58-1 ethyl nitrate 
• 62-23-7 4-nitro-benzoic acid 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 530-62-1 1,1'-carbonyldiimidazole 
• 4291-13-8 2-(4-nitrophenyl)-1,3,4-oxadiazole 
• 201230-82-2 carbon monoxide 
• 122-04-3 4-nitro-benzoyl chloride 
• 124-38-9 carbon dioxide 
• 555-16-8 4-nitrobenzaldehdye 
• 1422157-58-1 N′-[chloro-(4-nitrophenyl)methylene]-tert-butylcarbazate 
• 132509-33-2 N-t-butoxycarbonyl-N'-4-nitrobenzaldehyde hydrazone 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 861536-01-8 1-(4-amino-benzoyl)-carbonohydrazide 
• 113118-47-1 5-(4-aminophenyl)-1,3,5-oxadiazol-2-ol 
• 113118-47-1 5-(4-aminophenyl)-1,3,4-oxadiazol-2(3H)-one 
• 121649-40-9 N-(3,5-Dioxo-1-phenyl-[1,2,4]triazolidin-4-yl)-4-nitro-benzamide 
• 85916-63-8 3-Chloromethyl-5-(4-nitro-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 85916-60-5 3-Hydroxymethyl-5-(4-nitro-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 83725-85-3 N-(2,4-Dioxo-1,4-dihydro-2H-quinazolin-3-yl)-4-nitro-benzamide 
• 121649-32-9 5-(4-Nitro-phenyl)-2-oxo-[1,3,4]oxadiazole-3-carboxylic acid N-phenyl-N'-[1-phenyl-meth-(E)-ylidene]-hydrazide 
• 129221-14-3 N-(4-Benzyl-2,5-dioxo-imidazolidin-1-yl)-4-nitro-benzamide 
• 62121-05-5 3-isopropyl-5-(4-nitro-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 41125-94-4 2-isopropoxy-5-(4-nitro-phenyl)-[1,3,4]oxadiazole 
• 41125-93-3 2-(4-nitro-phenyl)-5-propoxy-[1,3,4]oxadiazole 
• 41126-10-7 5-(4-nitro-phenyl)-3-propyl-3H-[1,3,4]oxadiazol-2-one 
• 3206-36-8 2-ethoxy-5-(4-nitrophenyl)-1,3,4-oxadiazole 

Relevant articles and documents

DMF as Methine Source: Copper-Catalyzed Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles

An unprecedented Cu-catalyzed direct annulation of hydrazides with N,N-dimethylformamide (DMF) was developed, providing an efficient synthesis of valuable 1,3,4-oxadiazoles. This process features the short reaction time and can be safely conducted on gram scale. The reaction also facilitated the convenient synthesis of 1,3,4-oxadiazole-2(3H)-ones. Moreover, the mechanistic studies suggest that the source of CH is from the N-methyl group of DMF. (Figure presented.).

Synthesis of 5-substituted-3H-[1,3,4]-oxadiazol-2-one derivatives: A carbon dioxide route (CDR)

A carbon dioxide route (CDR) for making biologically important 5-substituted-3H-[1,3,4]-oxadiazol-2-ones (SHOs) has been accomplished through synthesis and cyclization of a variety of hydrazides as the key intermediates. All of these hydrazides were prepared readily in 89-97% yields by reacting acid chlorides with a hydrazine monohydrate in the initial step. Then, SHOs were obtained in high yields from hydrazides by reacting them with carbon dioxide under basic conditions. More notable than the high yields, is that the present CDR process for the first time has succeeded in providing a straightforward cyclization reaction leading to SHO formation with simple reagents in ethanol solution.

THIAZOLE DERIVATIVES AND USE THEREOF

The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.