119982-65-9

Upstream product

• 31431-10-4 2-amino-4-methylthio-1-nitrobenzene 
• 2106-50-5 2-chloro-4-fluoro-1-nitrobenzene 
• 5188-07-8 sodium thiomethoxide 
• 857786-53-9 bis-(3-acetylamino-4-nitro-phenyl)-disulfide 
• 5443-33-4 N-(5-chloro-2-nitrophenyl)acetamide 
• 119982-64-8 3-chloro-4-nitrobenzenethiol 
• 74-88-4 methyl iodide 

Downstream Products

• 20901-66-0 2-chloro-4-methylthiobenzeneamine 
• 60854-81-1 2-chloro-4-(methylsulfonyl)-1-nitrobenzene 
• 13244-35-4 2-chloro-4-(methylsulfonyl)aniline 

Relevant academic research and scientific papers

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Studies on antiinflammatory agents. II. Synthesis and pharmacological properties of 2'-(phenylthio)methanesulfonanilides and related derivatives

The structure of the previously reported new antiinflammatory agent (1, FK3311) was chemically modified in an attempt to find novel compounds with more potent and broader-spectrum activities. Some 2'-(phenylthio) and 2'-(phenylamino)methanesulfonanilides