20901-66-0

Upstream product

• 139696-89-2 N-(4-(methylsulfinyl)phenyl)acetamide 
• 119982-65-9 (3-chloro-4-nitrophenyl)(methyl)sulfane 
• 3226-47-9 4-amino-3-chlorophenyl thiocyanate 
• 74-88-4 methyl iodide 
• 95-51-2 o-chloroaniline 
• 67-56-1 methanol 
• 857786-53-9 bis-(3-acetylamino-4-nitro-phenyl)-disulfide 
• 31431-10-4 2-amino-4-methylthio-1-nitrobenzene 
• 5443-33-4 N-(5-chloro-2-nitrophenyl)acetamide 
• 1635-61-6 5-chloro-2-nitroaniline 
• 7647-01-0 hydrogenchloride 

Relevant academic research and scientific papers

Electrochemical and direct C-H methylthiolation of electron-rich aromatics

The electrochemical-induced C-H methylthiolation of electron-rich aromatics has been accomplished via a three component cross-coupling strategy. Potassium thiocyanate (KSCN) as both the supporting electrolyte and sulfur source and methanol as the methylation reagent are used. This protocol is versatile for various (hetero)aromatic compounds such as aniline, anisole and indole. The reaction proceeds under mild conditions without any metal catalyst, exogenous oxidant and highly toxic sulfur reagent. Importantly, such an electrochemical-induced methylthiolated reaction could be easily scaled up with good efficiency.

Metabolites of 2,4-Dichloro-1-nitrobenzene by Mucor javanicus

Metabolism of 2,4-dichloro-1-nitrobenzene (1) by Mucor javanicus AHU 6010 was investigated.In addition to the corresponding benzenamine derivative (2), two novel metabolites detected gas-chromatographically were extracted from the culture medium and isolated.The structures were unequivocally elucidated to be 4-chloro-2-methylthio-1-nitrobenzene (3) and 4-chloro-2-methylthiobenzenamine (4), respectively, by direct comparisons with authentic compounds.It was suggested that two biological reactions, namely, reduction of the nitro group and/or substitution of the ortho-chlorine atom by a methylthio group, were responsible for the formation of these metabolites.