120016-98-0

Usage

Uses

Used in Organic Synthesis:
(2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-5-(3-(2,2,2-TRIFLUOROACETAMIDO)PROP-1-YNYL)-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE is used as a protecting group or intermediate in organic synthesis for its versatile functional groups that facilitate complex chemical reactions.
Used in Drug Development:
In the pharmaceutical industry, (2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-5-(3-(2,2,2-TRIFLUOROACETAMIDO)PROP-1-YNYL)-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE is used as a building block or precursor in the development of new drugs, owing to the presence of bioactive groups such as the dihydropyrimidinyl and trifluoroacetamido moieties, which can contribute to the compound's therapeutic potential.
Used in Chemical Research:
(2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-5-(3-(2,2,2-TRIFLUOROACETAMIDO)PROP-1-YNYL)-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE serves as a subject of study in chemical research, where its unique structure and properties can be explored for novel applications and to enhance understanding of complex organic chemistry.

Upstream product

• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 
• 120016-97-9 5-(3-trifluoroacetamidopropargyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 104375-88-4 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine 
• 14719-21-2 trifluoroacetyl-propargyl amine 

Relevant academic research and scientific papers

Accurate distance determination of nucleic acids via foerster resonance energy transfer: Implications of dye Linker length and rigidity

In Foerster resonance energy transfer (FRET) experiments, the donor (D) and acceptor (A) fluorophores are usually attached to the macromolecule of interest via long flexible linkers of up to 15 A in length. This causes significant uncertainties in quantit

Functionalization of mono- and oligonucleotides with phosphane ligands by amide bond formation

Seven phosphane-functionalized deoxyuridines have been prepared by amide bond formation between aminodeoxyuridines and phosphanylcarboxylic acids. X-ray crystal structures for two of these new modified nucleosides have been obtained. The same coupling method has been extended to oligonucleotides. The phosphane containing strands have been purified and characterized by MALDI-TOF and, for the first time, 31P NMR spectrometry. Coordination of a phosphane-modified 15-mer to a [PdCl(η3-allyl)] moiety has been confirmed by 31P NMR spectroscopy.

Application of a highly robust and efficient fluorescence-resonance-energy- transfer (FRET) system in DNA

We report a feasibility study for the application of our newly developed highly efficient and robust fluorescence-resonance-energy-transfer (FRET) system to DNA. A 2′-oligodeoxynucleotide, 12, equipped with a quinolinone derivative as donor and a (bathoph

OLIGONUCLEOTIDE LABELLING: A CONCISE SYNTHESIS OF A MODIFIED THYMIDINE PHOSPHORAMIDITE

The condensation of 5'-dimethoxytrityl-5-iodo-2'-deoxyuridine (1) with N-trifluoroacetylpropargylamine (2) in the presence bis(triphenylphosphine) Pd(II) chloride and copper(I) iodide and subsequent conversion to the 3'-phosphoramidite (4) is an efficient