9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>hypoxanthine

Base Information

Chemical Name:9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>hypoxanthine
CAS No.:120033-38-7
Molecular Formula:C₂₈H₂₉N₄O₉P
Molecular Weight:596.533
Hs Code.:

Synonyms:9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>hypoxanthine

Suppliers and Price of 9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>hypoxanthine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>hypoxanthine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>hypoxanthine

There total 8 articles about 9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>hypoxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 120033-37-6
9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>-2-bromohypoxanthine

: 120033-38-7
9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>hypoxanthine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 3102.9 Torr;
DOI:10.1021/jm00126a027

Reference yield:

: 87781-93-9
2-bromo-1,9-dihydro-6H-purin-6-one

: 120033-38-7
9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>hypoxanthine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Et₃N; 2.) PPh₃, diethyl azodicarboxylate; 3.) 80 percent HOAc / 1.) 100 deg C, 2 h; 2.) dioxane, 80 deg C, 6 h; 3.) 80 deg C

3: 75 percent / CF₃SO₃SiMe₃ / acetonitrile / 0 deg C, 4 h; rt, 16 h

4: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile

5: hydrogen / Pd/C / 16 h / 3102.9 Torr / Ambient temperature

With trimethylsilyl trifluoromethanesulfonate; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In acetonitrile;
DOI:10.1039/c39890001769

Reference yield:

: 654075-03-3
1-O-acetyl-2,3-di-O-benzoyl-5-deoxy-5-(diethoxyphosphinyl)-α-D-ribofuranose

: 120033-38-7
9-<5'-deoxy-2',3'-di-O-benzoyl-5'-(diethoxyphosphinyl)-β-D-ribofuranosyl>hypoxanthine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) (NH₄)2SO₄, HMDS / 2.) TMS triflate / 1.) reflux 4 h, 2.) CH₃CN, r.t., 48 h

2: 90 percent / H₂ / Pd/C / ethanol / 3102.9 Torr

With ammonium sulfate; hydrogen; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; trimethylsilyl trifluoromethanesulfonate; In ethanol;
DOI:10.1021/jm00126a027