1200722-63-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(3′,4′-dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanenitrile is used as a building block for the synthesis of complex molecules, particularly in the development of new drugs. Its unique structure and properties make it a promising candidate for pharmaceutical applications.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(3′,4′-dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanenitrile is used as a starting material for the development of new agrochemicals. Its specific properties may contribute to the creation of innovative and effective products for agricultural use.
Used in Materials Science:
1-(3′,4′-dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanenitrile also has potential applications in materials science, where its unique structure and properties could be utilized in the development of new materials with specific characteristics.

Upstream product

• 96-49-1 [1,3]-dioxolan-2-one 
• 1200722-56-0 2-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-acetonitrile 
• 499983-13-0 2-( 4-bromo-3-fluorophenyl)acetonitrile 
• 452-74-4 4-bromo-3-fluorotoluene 
• 127425-73-4 1-bromo-4-(bromomethyl)-2-fluorobenzene 
• 749269-73-6 1-(4-bromo-3-fluorophenyl)cyclopropane-1-carbonitrile 
• 151169-75-4 3,4-dichlophenylboronic acid 
• 106-93-4 ethylene dibromide 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-FLUORO[1,1'-BIPHENYL]-4-YL)-CYCLOPROPANECARBOXYLIC ACID

The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group ?wherein R is as defined above and G is —CN or —COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain.

IMPROVED PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-FLUORO[1,1'-BIPHENYL]-4-YL)-CYCLOPROPANECARBOXYLIC ACID

The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: formula (I) wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: formula (II) wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group (formula) wherein R is as defined above and G is -CN or -COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain.

PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID

The invention relates to a process for the preparation of a compound of formula (IA).

PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2- HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID

Compounds according to formula (IA): may be efficiently prepared by the disclosed process.

PROCESS OF PREPARING DERIVATIVES OF 1-(2-HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID

Compounds represented by formula (I): may be conveniently prepared by a process in which a Suzuki reaction is performed as an early step.