120086-34-2

Basic information

• Product Name: 1-(4-Fluorophenyl)-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 1-(4-Fluorophenyl)-1,2,3,4-tetrahydroisoquinoline;Isoquinoline, 1-(4-fluorophenyl)-1,2,3,4-tetrahydro-
• CAS NO: 120086-34-2
• Molecular Formula: C₁₅H₁₄FN
• Molecular Weight: 227.281
• Mol File: 120086-34-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 88-89 ºC
• Boiling Point: 336.3 °C at 760 mmHg
• Flash Point: 157.2 °C
• Appearance: /
• Density: 1.132
• Vapor Pressure: 0.000113mmHg at 25°C
• Refractive Index: 1.573
• PKA: 8.84±0.40(Predicted)
• CAS DataBase Reference: 1-(4-Fluorophenyl)-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenyl)-1,2,3,4-tetrahydroisoquinoline(120086-34-2)
• EPA Substance Registry System: 1-(4-Fluorophenyl)-1,2,3,4-tetrahydroisoquinoline(120086-34-2)

Safety Data

• Hazardous Substances Data: 120086-34-2(Hazardous Substances Data)

Usage

General Description

1-(4-Fluorophenyl)-1,2,3,4-tetrahydroisoquinoline is a chemical compound with a tetrahydroisoquinoline core structure and a fluorophenyl substituent. It is a potentially useful building block for the synthesis of various biologically active compounds due to its structural features. The presence of the fluorophenyl group can potentially confer specific properties to the molecule, such as altered reactivity or interactions with biological targets. 1-(4-Fluorophenyl)-1,2,3,4-tetrahydroisoquinoline may have potential applications in medicinal chemistry, pharmaceuticals, and materials science due to its unique structure and potential biological activities. Further research is needed to fully understand its chemical properties and potential applications.

InChI:InChI=1/C15H14FN/c16-13-7-5-12(6-8-13)15-14-4-2-1-3-11(14)9-10-17-15/h1-8,15,17H,9-10H2

Upstream product

• 344261-84-3 1-(4-fluorophenyl)-3,4-dihydroisoquinoline 
• 456-22-4 4-Fluorobenzoic acid 
• 403-43-0 4-fluorobenzoyl chloride 
• 33799-96-1 N-(2-phenylethyl)-4-fluorobenzamide 
• 64-04-0 phenethylamine 

Downstream Products

• 180272-38-2 ethyl 1-(4-fluorophenyl)-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate 

Relevant articles and documents

Discovery of quinuclidine modulators of cellular progranulin

Phenotypic screening of an annotated small molecule library identified the quinuclidine tetrahydroisoquinoline solifenacin (1) as a robust enhancer of progranulin secretion with single digit micromolar potency in a murine microglial (BV-2) cell line. Subsequent SAR development led to the identification of 29 with a 38-fold decrease in muscarinic receptor antagonist activity and a 10-fold improvement in BV-2 potency.

Diprotonative stabilization of ring-opened carbocationic intermediates: conversion of tetrahydroisoquinoline to triarylmethanes

Superacid-promoted conversion of tetrahydroisoquinolines to triarylmethanes via tandem reactions of C-N bond scission, Friedel-Crafts alkylation, C-O bond scission, and electrophilic aromatic amidation was developed. Dication formation was important for stabilizing the ring-opened carbocationic intermediate, which is a new role for diprotonation in reaction mechanisms. This journal is

Phencyclidine-like Effects of Tetrahydroisoquinolines and Related Compounds

A series of 1,2,3,4-tetrahydroisoquinolines, tetrahydrothienopyridines, and related compounds were evaluated for their ability to inhibit binding of -1--N-allylnormetazocine to phencyclidine (PCP) and ? receptors, respectively.A representative series of compounds was evaluated in behavioral assays to determine the ability of the compounds to induce PCP-like stereotyped behavior and ataxia.All of the compounds caused stereotyped behavior and ataxia, indicating their agonist actions at the PCP site.