1201079-16-4

Upstream product

• 1201080-46-7 5-acetamido-4-ethoxy-2-nitrobenzoyl chloride 
• 1201080-20-7 methyl 3-acetamido-4-ethoxybenzoate 
• 1356916-92-1 3-acetamido-4-ethoxybenzoic acid 
• 1201080-29-6 5-acetamido-4-ethoxy-2-nitrobenzoic acid 
• 1201079-42-6 ethyl 3-(5-acetamido-4-ethoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate 
• 126360-59-6 methyl 3-(N-acetyl)amino-4-hydroxybenzoate 
• 536-25-4 methyl 3-amino-4-hydroxybenzoate 
• 1571-72-8 3-amino-4-hydroxybenzoic acid 
• 1201079-07-3 1-(3-acetamido-4-ethoxyphenyl)ethanone 
• 1201079-10-8 1-(5-acetamido-4-ethoxy-2-nitrophenyl)ethanone 
• 773837-37-9 sodium cyanide 
• 1201079-13-1 1-(5-acetamido-4-ethoxy-2-nitrophenyl)-2-bromoethanone 

Downstream Products

• 1201080-09-2 N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide 
• 1201079-19-7 N-{5-[2-cyano-3-(N,N-dimethylamino)acryloyl]-2-ethoxy-4-nitrophenyl}acetamide 
• 1201079-53-9 5-acetamido-2-amino-4-ethoxybenzoylacetonitrile 

Relevant academic research and scientific papers

New and practical synthesis of N-(3-Cyano-7-ethoxy-4-oxo-1,4- dihydroquinolin-6-yl)acetamide

New and practical synthetic route of N-(3-cyano-7-ethoxy-4-oxo-1,4- dihydroquinolin-6-yl)acetamide (1) is described, through the cyclization of 2-aminophenyl-ethanone (12) with N,N-dimethylformamide dimethylacetal. The overall yield of 1 obtained from this process is 46% (five steps) with a purity of >99% (HPLC).

Synthesis of n-(3-cyano-7-ethoxy-1,4-dihydro-4-oxoquinolin-6-yl)acetamide

New route for the preparation of N-(3-cyano-7-ethoxy-1,4-dihydro-4- oxoquinolin-6-yl)acetamide (1), a key intermediate for the synthesis of selective EGFR kinase inhibitors, was described.