120134-14-7

Usage

Uses

Used in Pharmaceutical Industry:
(2R,3R)-2-Benzoylamino-3-hydroxy-2-methyl-butyric acid methyl ester is used as a key intermediate in the synthesis of various pharmaceuticals and drug candidates. Its unique structural properties and functional groups enable the development of new drugs and pharmaceutical products with potential therapeutic applications.
Used in Medicinal Chemistry Research:
(2R,3R)-2-Benzoylamino-3-hydroxy-2-methyl-butyric acid methyl ester serves as a valuable building block in medicinal chemistry research, allowing scientists to explore its potential in the design and synthesis of novel biologically active compounds with therapeutic potential.

Upstream product

• 88318-69-8 (4R,5S)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 114041-65-5 trans-methyl 3-hydroxy-2-methyl-2-aminobutanoate hydrochloride 
• 7471-86-5 methyl benzimidate 
• 120133-99-5 trans-4-(methoxycarbonyl)-4-methyl-5-methyl-2-oxazoline 
• 88318-69-8 (4R,5R)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 120134-14-7 (2R,3R)-2-Benzoylamino-3-hydroxy-2-methyl-butyric acid methyl ester 
• 112979-39-2 methyl N-benzoyl-DL-β-homoalaninate 
• 112979-44-9 (l)-3-(Benzoylamino)-2-methylbuttersaeure-methylester 
• 120134-14-7 (2R,3S)-2-Benzoylamino-3-hydroxy-2-methyl-butyric acid methyl ester 

Downstream Products

• 88318-69-8 (4R,5S)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 120134-14-7 (2R,3R)-2-Benzoylamino-3-hydroxy-2-methyl-butyric acid methyl ester 
• 88318-69-8 (4R,5R)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 120134-14-7 (2R,3S)-2-Benzoylamino-3-hydroxy-2-methyl-butyric acid methyl ester 

Relevant academic research and scientific papers

Synthesis and ring opening of methyl 2-alkyl-3-(alkyl/aryl)-1- benzoylaziridine-2-carboxylates: Synthesis of polysubstituted amino acids

A new method for the preparation of 2,2,3-trisubstituted methyl 1- benzoylaziridine-2-carboxylates is reported. These compounds have been obtained starting from α-alkyl β-amino acids by formation of the lithium dianion and reaction with iodine. The aziridines undergo ring expansion or ring opening, depending on the substituents of the aziridine ring and on the reaction conditions. Following these methods, both α-substituted α-hydroxy β-amino acids and α-substituted β-hydroxy α-amino acids have been synthesised.

ASYMMETRIC SYNTHESIS OF β-HYDROXY-α-ALKYLAMINO ACIDS BY ASYMMETRIC ALDOL REACTION OF α-ISOCYANOCARBOXYLATES CATALYZED BY CHIRAL FERROCENYLPHOSPHINE-GOLD(I) COMPLEXES

Aldol reaction of methyl α-isocyanocarboxylates (CNCH(R)COOMe: R = H, Me, Et, i-Pr) with benzaldehyde or acetaldehyde in the presence of 0.5-1.0 molpercent of a chiral (aminoalkyl)ferrocenylphosphine-gold(I) complex gave optically active 4-methoxycarbonyl