88318-69-8

Basic information

• Product Name: (4R,5S)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester
• CAS NO: 88318-69-8
• Molecular Weight: 233.267
• Mol File: 88318-69-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4R,5S)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester(88318-69-8)
• EPA Substance Registry System: (4R,5S)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester(88318-69-8)

Safety Data

• Hazardous Substances Data: 88318-69-8(Hazardous Substances Data)

Upstream product

• 120134-14-7 (2R,3S)-2-Benzoylamino-3-hydroxy-2-methyl-butyric acid methyl ester 
• 88318-69-8 (4R,5R)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 120133-99-5 trans-4-(methoxycarbonyl)-4-methyl-5-methyl-2-oxazoline 
• 114041-65-5 trans-methyl 3-hydroxy-2-methyl-2-aminobutanoate hydrochloride 
• 7471-86-5 methyl benzimidate 
• 120134-14-7 (2R,3R)-2-Benzoylamino-3-hydroxy-2-methyl-butyric acid methyl ester 
• 88318-69-8 (4R,5S)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 60538-17-2 (4S,5R)-4-methyl-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid methyl ester 
• 88318-67-6 Lithium; methoxy-[(R)-5-methyl-2-phenyl-oxazol-(4E)-ylidene]-methanolate 
• 74-88-4 methyl iodide 
• 82659-84-5 (4S,5S)-5-methyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 

Downstream Products

• 88318-69-8 (4R,5S)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 120134-14-7 (2R,3S)-2-Benzoylamino-3-hydroxy-2-methyl-butyric acid methyl ester 
• 88318-69-8 (4R,5R)-4,5-Dimethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 120134-14-7 (2R,3R)-2-Benzoylamino-3-hydroxy-2-methyl-butyric acid methyl ester 
• 114179-07-6 (2S,3S)-α-methylthreonine 

Relevant articles and documents

ASYMMETRIC SYNTHESIS OF β-HYDROXY-α-ALKYLAMINO ACIDS BY ASYMMETRIC ALDOL REACTION OF α-ISOCYANOCARBOXYLATES CATALYZED BY CHIRAL FERROCENYLPHOSPHINE-GOLD(I) COMPLEXES

Aldol reaction of methyl α-isocyanocarboxylates (CNCH(R)COOMe: R = H, Me, Et, i-Pr) with benzaldehyde or acetaldehyde in the presence of 0.5-1.0 molpercent of a chiral (aminoalkyl)ferrocenylphosphine-gold(I) complex gave optically active 4-methoxycarbonyl

α-ALKYLATION OF THREONINE

The (S,S)- and the (S,R)-oxazolines 4, both readily available from L-threonine, are deprotonated with lithium diisopropylamide (LDA, -> 5) and alkylated diastereoselectively (>95 percent ds) to yield the 4,4-disubstituted oxazolines 7.The product of methy