1201934-67-9

Upstream product

• 64517-88-0 1,3-dimethyl-1H-pyrazol-4-amine 
• 1061358-71-1 2-((2-chloro-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide 
• 3524-32-1 5-Amino-1,3-dimethylpyrazole 
• 118-48-9 isatoic anhydride 
• 4141-08-6 2-Amino-N-methylbenzamid 
• 505084-55-9 2-chloro-4-iodo-5-(trifluoromethyl)pyridine 

Relevant academic research and scientific papers

Two-directional approach for the rapid synthesis of 2,4-bis-aminoaryl pyridine derivatives

We have developed two different approaches in parallel to rapidly access 2,4-bis aminoaryl pyridine compounds from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then C-2. An alternative C-2/C-4 route uses a regioselective SNAr reaction to first substitute at C-2 then subsequently at C-4 by a palladium-mediated reaction. Both approaches have been used successfully to provide a range of 2,4-bis-aminoaryl pyridine compounds.

PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK

The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.

PYRIDINE COMPOUNDS

The present invention relates to compounds that inhibit of focal adhesion kinase function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases such as cancer.