120230-90-2Relevant articles and documents
Microwave-assisted sequential amide bond formation and intramolecular amidation: A rapid entry to functionalized oxindoles
Poondra, Rajamohan R.,Turner, Nicholas J.
, p. 863 - 866 (2005)
(Chemical Equation Presented) A general method has been developed for the synthesis of N-substituted oxindoles. The two-step process involves initial microwave-assisted amide bond formation between 2-halo-arylacetic acids and various alkylamines and anilines, followed by a palladium-catalyzed intramolecular amidation under aqueous conditions. In the case of alkylamines, the procedure can be carried out as a one-pot process without isolation of the intermediate amide.
Copper-catalyzed transformation of alkyl nitriles to N -arylacetamide using diaryliodonium salts
Sallio, Romain,Payard, Pierre-Adrien,Pakulski, Pawe?,Diachenko, Iryna,Fabre, Indira,Berteina-Raboin, Sabine,Colas, Cyril,Ciofini, Ilaria,Grimaud, Laurence,Gillaizeau, Isabelle
, p. 15885 - 15889 (2021/05/19)
This work reports a simple and efficient method for the copper-catalyzed redox-neutral transformation of alkyl nitriles using eco-friendly diaryliodonium salts and leading to N-arylacetamides. The method features high efficiency, broad substrate scope and good functional group tolerance.
Copper-catalyzed aerobic oxidative annulation and carbon-carbon bond cleavage of arylacetamides: Domino synthesis of fused quinazolinones
Sun, Jie,Tan, Qitao,Yang, Wusong,Liu, Bingxin,Xu, Bin
supporting information, p. 388 - 394 (2014/05/20)
An efficient copper-catalyzed tandem aerobic oxidative annulation and carbon-carbon bond cleavage reaction was developed from easily accessible arylacetamides, which provides a direct approach for the domino synthesis of a vast array of tricyclic or tetracyclic fused quinazolinone alkaloid structures. A plausible reaction mechanism is proposed involving an aerobic benzylic oxidation/ cyclization/decarbonylation cascade.
