1202377-97-6

Basic information

• Product Name: (S)-2-methyltetrahydropyran-4-ol
• CAS NO: 1202377-97-6
• Molecular Weight: 116.16
• Mol File: 1202377-97-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-methyltetrahydropyran-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-methyltetrahydropyran-4-ol(1202377-97-6)
• EPA Substance Registry System: (S)-2-methyltetrahydropyran-4-ol(1202377-97-6)

Safety Data

• Hazardous Substances Data: 1202377-97-6(Hazardous Substances Data)

Upstream product

• 1193-20-0 2-methyltetrahydro-4H-pyran-4-one 
• 67-63-0 isopropyl alcohol 
• 190912-15-3 (2S)-2-methyl-2,3-dihydropyran-4-one 

Relevant articles and documents

Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction

A biocatalytic cascade to produce tert-butyl ((2R,4R)-2-methyltetrahydro-2H-pyran-4-yl)carbamate 6 has been demonstrated at the multikilogram scale. In this reaction, a racemic ketone is resolved by reducing the undesired ketone using a ketone reductase (KRED). The reduction is stereospecific for the 2-position of substrate (2S)-ketone leaving the (2R)-ketone unreacted. After the (2S)-ketone has been depleted, a transaminase is added to catalyze the enantioselective transamination of the ketone, resulting in formation of the (2R, 4R)-amine 6. The product is recovered from the aqueous reaction after Boc protection.