1202634-06-7

Basic information

• Product Name: 5-(tert-butyl)-3-phenylbenzofuran
• Synonyms: 5-(tert-butyl)-3-phenylbenzofuran
• CAS NO: 1202634-06-7
• Molecular Weight: 250.34
• Mol File: 1202634-06-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5-(tert-butyl)-3-phenylbenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(tert-butyl)-3-phenylbenzofuran(1202634-06-7)
• EPA Substance Registry System: 5-(tert-butyl)-3-phenylbenzofuran(1202634-06-7)

Safety Data

• Hazardous Substances Data: 1202634-06-7(Hazardous Substances Data)

Upstream product

• 38941-98-9 4-tert-butyl-2-iodophenol 
• 70-11-1 α-bromoacetophenone 
• 98-54-4 para-tert-butylphenol 
• 901408-74-0 2-(4-(tert-butyl)phenoxy)-1-phenylethanone 
• 127-19-5 N,N-dimethyl acetamide 
• 10425-05-5 (5-(tert-butyl)-2-hydroxyphenyl)(phenyl)methanone 
• 100-42-5 styrene 

Relevant articles and documents

Nickel-Catalyzed Intramolecular Nucleophilic Addition of Aryl Halides to Aryl Ketones for the Synthesis of Benzofuran Derivatives

A nickel-catalyzed intramolecular nucleophilic addition reaction of aryl halides to aryl ketones for the formation of benzofuran derivatives has been developed. A number of substrates bearing electron-donating or electron-withdrawing groups were subjected to the standard reaction conditions, giving the corresponding products in moderate to good yields.

Nickel catalyzed intramolecular oxidative coupling: synthesis of 3-aryl benzofurans

Recent research has been focused on the transition metal-catalyzed reactions. Herein we have developed nickel-catalyzed synthesis of 3-aryl benzofurans fromortho-alkenyl phenolsviaintramolecular dehydrogenative coupling. Notably, simple O2gas served as an oxidant, without using any sacrificial hydrogen acceptor. The strategy enabled the synthesis of 3-aryl benzofurans in good to excellent yields.

Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)participates in diverse cancer-associated signaling pathways, playing an oncogenic role in multiple human cancers, including hepatocellular carcinoma (HCC). Our recent works clarify that Pin1 modulates miRNAs biogenesis by interacting with ERK-phosphorylated exportin-5 (XPO5)and changing XPO5 conformation, giving a potential target for HCC treatment. Herein, we discover 4,6-bis(benzyloxy)-3-phenylbenzofuran (TAB29)as a novel Pin1 inhibitor that targets Pin1 PPIase domain. TAB29 potently inhibits Pin1 activity with the IC50 value of 874 nM and displays an excellent selectivity toward Pin1 in vitro. Cell-based biological evaluation reveals that TAB29 significantly suppresses cell proliferation of HCC cells through restoring the nucleus-to-cytoplasm export of XPO5 and upregulating mature miRNAs expression. Collectively, this work provides a promising small molecule lead compound for Pin1 inhibition, highlighting the therapeutic potential of miRNA-based treatment for human cancers.