120342-74-7

Upstream product

• 119-61-9 benzophenone 
• 102-82-9 tributyl-amine 
• 24892-82-8 1-bromo-2-(1-phenylpropen-1-yl)benzene 
• 107-02-8 acrolein 
• 99668-09-4 o-phenylcinnamaldehyde 
• 413615-57-3 2-(2,2-diphenyl-cyclopropylmethyl)-[1,3]dioxolane 
• 413615-56-2 2-(3,3-diphenyl-allyl)-[1,3]dioxolane 
• 413615-58-4 (2,2-diphenylcyclopropyl)acetaldehyde 
• 14189-82-3 3-(N-Methylanilino)-2-propenal 
• 129975-62-8 [3-(1,3-dioxolan-2-yl)allyl]phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Highly Stereoselective Synthesis of 1,3-Dienes through an Aryl to Vinyl 1,4-Palladium Migration/Heck Sequence

An efficient aryl to vinyl 1,4-palladium migration/Heck sequence was developed for the stereoselective synthesis of 1,3-dienes. High stereoselectivity was observed not only for 1,3-dienes bearing two similar aryl groups at terminal positions, but also for

Iodine(V) reagents in organic synthesis. Part 4. o-Iodoxybenzoic acid as a chemospecific tool for single electron transfer-based oxidation processes

o-Iodoxybenzoic acid (IBX), a readily available hypervalent iodine(V) reagent, was found to be highly effective in carrying out oxidations adjacent to carbonyl functionalities (to form α, β-unsaturated carbonyl compounds) and at benzylic and related carbon centers (to form conjugated aromatic carbonyl systems). Mechanistic investigations led to the conclusion that these new reactions are initiated by single electron transfer (SET) from the substrate to IBX to form a radical cation which reacts further to give the final products. Fine-tuning of the reaction conditions allowed remarkably selective transformations within multifunctional substrates, elevating the status of this reagent to that of a highly useful and chemoselective oxidant.

Metalation of iminium ions formed in the reaction of tertiary amines with TiCl4

(equation presented) TiCl4 reacts with trialkylamines at 0-25°C to give iminium ions that on metalation followed by reaction with diaryl ketones, produce α,β-unsaturated aldehydes.

Exclusive γ-regio functionalization of crotonaldehyde using γ-trimethylsilyl crotonaldimine. Application to the one pot synthesis of conjugated dienals

Cesium fluoride mediated reaction of γ-trimethylsilyl N-tert-butyl crotonaldimine 9 with a wide range of aldehydes takes place in DMSO at room temperature and affords exclusive γ-regio functionalized products. Heating (rt to 100°C) the δ-silyloxy imines 11 thus obtained leads, after very mild hydrolysis of the tert-butylimine function, to the conjugated dienals 14 in good yields and with excellent (E,E)-selectivities.

3,5-dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents

Variously substituted 3,5-dihydroxy-6,8-nonadienoic acids and esters, are blood cholesterol lowering agents and so are useful in the prevention and treatment of cardiovascular diseases such as atherosclerosis.

Polyunsaturated aldehydes by direct polyvinylogation of carbonyl compounds using functionalized phosphonates.

Carbonyl compounds are converted into polyethylenic aldehydes in a one pot reaction with the anions of phosphonates 1. followed by a mild acidic hydrolysis.