14189-82-3

Basic information

• Product Name: 3-(N-Phenyl-N-methyl)aminoacrolein
• Synonyms: 3-(N-PHENYL-N-METHYL)AMINOACROLEIN;3-N-METHYL-N-PHENYLAMINOACROLEIN;3-AMINO-N-METHYL-N-PHENYLACROLEIN;3-N-METHYL-N-PHENYLAMINOACROLEINI;3-(methyl(phenyl)amino)acrylaldehyde;N-Methyl-N-phenyl-3-aMinoacrolein;(E)-3-(Methyl(phenyl)aMino)acrylaldehyde;3-(Methyl-phenyl-aMino)-propenal
• CAS NO: 14189-82-3
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• EINECS: 1533716-785-6
• Product Categories: Fluvastatine;Fluvastatin
• Mol File: 14189-82-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 166 °C (decomp)
• Boiling Point: 255.6 °C at 760 mmHg
• Flash Point: 92.1 °C
• Appearance: /
• Density: 1.064 g/cm³
• Refractive Index: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Very Slightly)
• PKA: 1.07±0.70(Predicted)
• Stability: Air Sensitive
• CAS DataBase Reference: 3-(N-Phenyl-N-methyl)aminoacrolein(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(N-Phenyl-N-methyl)aminoacrolein(14189-82-3)
• EPA Substance Registry System: 3-(N-Phenyl-N-methyl)aminoacrolein(14189-82-3)

Safety Data

• Hazardous Substances Data: 14189-82-3(Hazardous Substances Data)

Usage

General Description

3-(N-Phenyl-N-methyl)aminoacrolein is a chemical compound that consists of an acrolein molecule with a substituted amino group. It is often used in organic synthesis and chemical research. 3-(N-Phenyl-N-methyl)aminoacrolein has a phenyl and a methyl group attached to the amino group, and it is known for its reactivity and ability to undergo various chemical reactions. It is a yellow solid at room temperature and can be volatile, making it important to handle with caution. 3-(N-Phenyl-N-methyl)aminoacrolein is a versatile compound that has potential applications in various fields, including pharmaceuticals, materials science, and industrial chemistry.

InChI:InChI=1/C10H11NO/c1-11(8-5-9-12)10-6-3-2-4-7-10/h2-9H,1H3

Upstream product

• 107-19-7 propargyl alcohol 
• 100-61-8 N-methylaniline 
• 111-34-2 -butyl vinyl ether 
• 93-61-8 N-methyl-N-phenylformamide 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 107-02-8 acrolein 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 624-67-9 Propargylic aldehyde 

Downstream Products

• 14251-15-1 7-(N-methyl-anilino)-hepta-2,4,6-trienal 
• 18829-56-6 (E)-2-Nonenal 
• 3913-81-3 (E)-2-decenal 
• 20884-05-3 (E)-3-(2-naphthyl)-2-propenal 
• 5362-56-1 4-methylpent-2-enal 
• 14371-10-9 (E)-3-phenylpropenal 
• 93872-94-7 [4-(1,3,3-trimethyl-indolin-2-ylidene)-but-2-enylidene]-malononitrile 
• 289-95-2 PYRIMIDINE 
• 20432-35-3 3-(4-dimethylamino-phenyl)-propenal 
• 56578-35-9 4-methyl-cinnamaldehyde 
• 126462-90-6 9-<3-(N-methyl-N-phenylamino)-2-propenylidene>-2,4,5,7-tetranitrofluorene 
• 121434-23-9 5-<3-(N-methyl-N-phenylamino)propenylidene>-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 20577-25-7 4-(N-Methylanilino)-1-cyano-1-carbethoxybutadien 

Relevant articles and documents

Cp2ZrCl2-catalyzed synthesis of 2-aminovinyl benzimidazoles under microwave conditions

A microwave-assisted general method for the synthesis of 2-aminovinyl benzimidazoles has been developed. Treatment of the 1,2-phenylenediamines and N-arylated/N,N-dialkylated 3-aminoacroleins with bis(cyclopentadienyl)zirconium(IV) dichloride (Cp2/s

Synthetic method for N-substituent-3-aminoacrolein

The invention discloses a synthetic method for N-substituent-3-aminoacrolein. The method comprises the following steps: with secondary amine and 3-chloroallyl alcohol as raw materials, and active manganese dioxide as a catalyst, carrying out introducing into an air environment, then carrying out a reaction at 0.5 to 2.5 MPa and 40 to 90 DEG C for 6 to 14 h, and after completion of the reaction, postprocessing a reaction solution so as to obtain an N-substituent-3-aminoacrolein derivative, wherein the yield is 68% to 97%. Compared with a conventional method for synthesizing the N-substituent-3-aminoacrolein, the method provided by the invention has the advantages of low toxicity, low pollution, simple operation, etc.

Facile and highly enantioselective synthesis of (+)- and (-)-fluvastatin and their analogues

A highly enantioselective synthesis of (+)- and (-)-fluvastatin and their analogues has been facilitated by the reaction of an aldehyde with diketene in the presence of Ti(O-i-Pr)4 and a chiral Schiff base ligand. Either enantiomer of the Schiff base could be employed to obtain (+)- or (-)-fluvastatin. Diastereoselective reductions of the resultant keto moiety of β-hydroxy ketoesters provided the syn-1,3-diol esters (91% ee), which were subsequently recrystallized and saponified to afford (+)- and (-)-fluvastatin in >99.9% ee.