120367-99-9

Upstream product

• 21286-78-2 methyl N-benzoyl-2-methoxyglycinate 
• 122-52-1 triethyl phosphite 
• 13716-45-5 diethyl trimethylsilyl phosphite 
• 19791-95-8 α-hydroxyhippuric acid 
• 90711-94-7 methyl 2-amino-2-(diethoxyphosphoryl)acetate 
• 98-88-4 benzoyl chloride 
• 114684-69-4 methyl 2-(benzyloxycarbonylamino)-2-(diethyloxyphosphoryl)acetate 

Downstream Products

• 150693-72-4 (Z)-2-Benzoylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pent-2-enoic acid methyl ester 
• 1370463-70-9 C₂₀H₂₀ClNO₆ 
• 301191-66-2 C₂₀H₁₈ClNO₆ 
• 150672-47-2 C₂₁H₁₇⁽²⁾HN₂O₅ 

Relevant academic research and scientific papers

Efficient synthesis of DOPA analogues in pepticinnamins E via asymmetric catalytic hydrogenation of dehydroamino esters

One practical synthetic procedure with five steps was developed to prepare a series of N-protected-2-(diethoxyphosphoryl)glycinates with good yields, which was treated with aldehydes under mild condition to give different dehydroamino esters with high yields and excellent Z/E selectivity. The subsequently homogeneous enantioselective hydrogenation of the dehydroamino esters affords a series of new DOPA analogues.

FACILE SYNTHESIS OF α-PHOSPHORYLATED α-AMINO ACIDS

Various α-phosphorylated α-amino acid derivatives were synthesized conveniently by the reaction of methyl α-methoxyhippurate and methyl α-methoxy-N-benzyloxycarbonyl-glycinate with phosphites under the Lewis acid.Hydrolysis of (12) with TMSI gave 2-phosph