1204-37-1

Upstream product

• 151445-99-7 6,8-diacetoxy-3-methylisocoumarin 
• 7664-93-9 sulfuric acid 
• 1206-69-5 2-carboxy-3,5-dihydroxybenzylmethyl ketone 
• 7647-01-0 hydrogenchloride 
• 53279-32-6 2,4-dihydroxy-6-pyruvoyl-benzoic acid 
• 1160239-13-3 C₁₇H₂₀O₉ 
• 122333-93-1 3-(3,5-dimethoxyphenyl)-2-methylpropenoic acid 
• 122333-94-2 3-(3,5-dimethoxyphenyl)-2-methylpropanoic acid 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 61227-55-2 4,6-dimethoxy-2-methylinden-3-yl trifluoroacetate 
• 61227-52-9 5,7-dimethoxy-2-methylindan-1-one 
• 6512-31-8 2,4-dimethoxy-6-(2-oxopropyl)benzoic acid 
• 4778-99-8 2-carboxymethyl-4,6-dimethoxy-benzoic acid 
• 18110-66-2 6,8‐dimethoxy‐3‐methylisocoumarin 

Downstream Products

• 1702-86-9 8-hydroxy-6-methoxy-3-methylisocoumarin 
• 18110-66-2 6,8‐dimethoxy‐3‐methylisocoumarin 

Relevant academic research and scientific papers

Inhibition of Plasmodium falciparum Lysyl-tRNA Synthetase via a Piperidine-Ring Scaffold Inspired Cladosporin Analogues

Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) represents a promising therapeutic anti-malarial target. Cladosporin was identified as a selective and potent PfKRS inhibitor but lacks metabolic stability. Here, we report chemical synthesis, biological evaluation and structural characterization of analogues where the tetrahydropyran (THP) frame of cladosporin is replaced with the piperidine ring bearing functional group variations. Thermal binding, enzymatic, kinetic and parasitic assays complemented with X-ray crystallography reveal compounds that are moderate in potency. Co-crystals of Cla?B and Cla?C with PfKRS reveal key atomic configurations that allow drug binding to and inhibition of the enzyme. Collectively these piperidine ring scaffold inhibitors lay a framework for further structural editing and functional modifications of the cladosporin scaffold to obtain a potent lead.

Synthetic method of isocoumarin aromatic ether compound

The invention discloses a synthetic method of an isocoumarin aromatic ether compound, which belongs to the technical field of synthesis of aromatic ether compounds, and discloses a novel aromatic ether compound, which has a specific synthetic route as fol

Isocoumarin glucosides from the scale insect fungus Torrubiella tenuis BCC 12732

Three new isocoumarin glucosides (1, 3, and 4), 6,8-dihydroxy-3- methylisocoumarin (2), and 6,8-dihydroxy-3-hydroxymethylisocoumarin (5) were isolated from the scale insect pathogenic fungus Torrubiella tenuis BCC 12732. Structures of these compounds were

BIOSYNTHESIS OF CANESCIN, A METABOLITE OF ASPERGILLUS MALIGNUS : INCORPORATION OF METHIONINE, ACETATE, SUCCINATE, AND ISOCOUMARIN PRECURSORS, LABELLED WITH DEUTERIUM AND CARBON-13

The biosynthesis of canescin (1), a metabolite of Aspergillus malignus, has been studied using methionine, sodium- and acetate, and sodium- and -succinate as simple precursors, and deuterium labelled isocoumarins as potential advanced precursors.Analysis of the labelled products by both n.m.r. and mass spectrometry suggests that 6,8-dihydroxy-3,7-dimethylisocoumarin (13) is the first enzyme-free intermediate produced by the polyketide synthase, and the 7-formyl-6,8-dihydroxy-3-methylisocoumarin (16) is a later intermediate on the pathway.Incorporation into canescin of (13)C together with one deuterium atom from methionine proves that the formyl group of (16) is derived from this source and that it is not oxidised to the level of a carboxylic acid in subsequent steps.The (13)C labels in the succinate units are incorporated into the γ-lactone carbons (C-11 to C-13) of canescin, but with complete loss of the neighbouring deuterium label.

Biosynthesis of Fungal Metabolites. Terrein, a Metabolite of Aspergillus terreus Thom

Terrein, a metabolite of Aspergillus terreus Thom, is biosynthesised from 3,4-dihydro-6,8-dihydroxy-3-methylisocoumarin by contraction of an aryl ring.The direction of the ring contraction has been investigated using acetate as precursor.