120409-48-5

Basic information

• Product Name: N-t-butyloxycarbonyl-DL-aspartic acid anhydride
• Synonyms: N-t-butyloxycarbonyl-DL-aspartic acid anhydride
• CAS NO: 120409-48-5
• Molecular Weight: 215.206
• Mol File: 120409-48-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: N-t-butyloxycarbonyl-DL-aspartic acid anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: N-t-butyloxycarbonyl-DL-aspartic acid anhydride(120409-48-5)
• EPA Substance Registry System: N-t-butyloxycarbonyl-DL-aspartic acid anhydride(120409-48-5)

Safety Data

• Hazardous Substances Data: 120409-48-5(Hazardous Substances Data)

Upstream product

• 56-84-8 L-Aspartic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13726-67-5 Boc-Asp-OH 
• 693-13-0 diisopropyl-carbodiimide 

Downstream Products

• 1360817-30-6 C₃₀H₂₉FN₄O₅S 
• 1360817-31-7 C₃₀H₂₉FN₄O₅S 
• 40856-59-5 tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate 
• 104227-71-6 N-[(3S)-tetrahydro-5-oxo-3-furanyl]carbamic acid-1,1-dimethylethyl ester 
• 117752-82-6 (S)-β-amino-γ-butyrolactone hydrochloride 
• 83345-44-2 3-<(tert-Butoxycarbonyl)amino>-4-hydroxy-L-butyric acid 
• 130052-03-8 2-tert-butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2-cyano-ethyl) ester 
• 130052-02-7 Boc-Asp(OChx)-OCet 
• 73821-95-1 Boc-Asp(O-cyclohexyl)-OH 
• 1676-90-0 Boc-Asp(OtBu)-OH 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 83345-44-2 3-tert-butoxycarbonylamino-4-hydroxy-butyric acid 
• 221106-60-1 (S)-3-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsiloxy)butyric acid benzyl ester 
• 129046-87-3 fluoren-9-ylmethyl N-tert-butyloxycarbonyl-L-aspartate 

Relevant articles and documents

Synthesis and antiaggregative activity of derivatives of 3-aminopiperidine-2,6-diones and 3-aminopyrrolidine-2,5-diones

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Polypeptide formation by heating N-t-butyloxycarbonyl acidic amino acid derivatives

An acid labile N-protecting group for amino acids, t-butyloxycarbonyl (Boc) group has deprotected at elevated temperatures. The study describes an application of the lability on heating to synthesis of polypeptides from acidic amino acids. t-Butyloxycarbonyl-acidic amino acids (aspartic acid, glutamic acid and β-aminoglutaric acid) and their anhydrides were heated at the higher temperatures than their melting points. Anhydrides of t-butyloxycarbonyl-aspartic acid and t-butyloxycarbonyl-β-aminoglutaric acid gave polypeptides. Thermal analyses of the substrates clarified the pathway of the polypeptide formation.

Bronsted base-assisted boronic acid catalysis for the dehydrative intramolecular condensation of dicarboxylic acids

Bronsted base-assisted boronic acid catalysis for the dehydrative self-condensation of carboxylic acids is described. Arylboronic acid bearing bulky (N,N-dialkylamino)methyl groups at the 2,6-positions can catalyze the intramolecular dehydrative condensation of di-and tetracarboxylic acids. This is the first successful method for the catalytic dehydrative self-condensation of carboxylic acids.(Figure Presented)