1609977-96-9

Basic information

• Product Name: 1-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}-3-methyl-1H-imidazol-3-ium trifluoroacetate
• Synonyms: 1-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}-3-methyl-1H-imidazol-3-ium trifluoroacetate
• CAS NO: 1609977-96-9
• Molecular Weight: 690.67
• Mol File: 1609977-96-9.mol

Chemical Properties

• CAS DataBase Reference: 1-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}-3-methyl-1H-imidazol-3-ium trifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}-3-methyl-1H-imidazol-3-ium trifluoroacetate(1609977-96-9)
• EPA Substance Registry System: 1-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}-3-methyl-1H-imidazol-3-ium trifluoroacetate(1609977-96-9)

Safety Data

• Hazardous Substances Data: 1609977-96-9(Hazardous Substances Data)

Upstream product

• 15177-67-0 trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid 
• 183996-94-3 trans-4-acetylcyclohexanecarboxylic acid methyl ester 
• 1204296-03-6 2-chloro-4-(difluoromethyl)pyridine 
• 73895-98-4 6-bromo-4-methylpyridine-2-amine 
• 1411772-41-2 6-bromo-N-(4-(difluoromethyl)pyridine-2-yl)-4-methylpyridine-2-amine 
• 1421930-35-9 trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid 
• 1609978-88-2 methyl trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 616-47-7 1-methyl-1H-imidazole 
• 1609978-89-3 chloromethyl trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 76-05-1 trifluoroacetic acid 
• 1411772-54-7 methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 1411772-44-5 methyl trans-4-[1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 32529-80-9 trans-1-chlorocarbonyl-4-(methoxycarbonyl)-cyclohexane 

Relevant articles and documents

PRODRUG BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS

The present invention provides compounds of Formula (I), which are prodrugs of trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid, a potent inhibitor of Syk. The compounds are useful in the treatment and prevention of diseases mediated by the enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.