1609978-82-6

Basic information

• Product Name: 1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate
• Synonyms: 1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate
• CAS NO: 1609978-82-6
• Molecular Weight: 723.817
• Mol File: 1609978-82-6.mol

Chemical Properties

• CAS DataBase Reference: 1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate(1609978-82-6)
• EPA Substance Registry System: 1-tert-butyl 4-{[({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl}piperidine-1,4-dicarboxylate(1609978-82-6)

Safety Data

• Hazardous Substances Data: 1609978-82-6(Hazardous Substances Data)

Upstream product

• 15177-67-0 trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid 
• 183996-94-3 trans-4-acetylcyclohexanecarboxylic acid methyl ester 
• 1204296-03-6 2-chloro-4-(difluoromethyl)pyridine 
• 73895-98-4 6-bromo-4-methylpyridine-2-amine 
• 1411772-41-2 6-bromo-N-(4-(difluoromethyl)pyridine-2-yl)-4-methylpyridine-2-amine 
• 1609978-88-2 methyl trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 1411772-54-7 methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 1411772-44-5 methyl trans-4-[1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 1421930-35-9 trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid 
• 150109-49-2 1-tert-butyl 4-(chloromethyl)piperidine-1,4-dicarboxylate 
• 32529-80-9 trans-1-chlorocarbonyl-4-(methoxycarbonyl)-cyclohexane 

Downstream Products

• 1609977-34-5 [({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)oxy]methyl piperidine-4-carboxylate 

Relevant articles and documents

PRODRUG BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS

The present invention provides compounds of Formula (I), which are prodrugs of trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid, a potent inhibitor of Syk. The compounds are useful in the treatment and prevention of diseases mediated by the enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.