1204485-80-2Relevant academic research and scientific papers
Synthesis and insecticidal activities of cis-configuration nitenpyram analogues with benzoyl hydrazines
Xu, Xiao,Sun, Chuan-Wen,Yang, Ding-Rong,Bu, Hong-Fei,Wang, Jing,Xu, Yong-Hua
, p. 945 - 948 (2013)
To research on the structure-activity relationships of our designed neonicotinoid compounds, a series of novel cis-configuration nitenpyram analogues with benzoyl hydrazines were designed and synthesized. The structures of all compounds were confirmed by IR, 1H NMR, MS, and elemental analysis. Preliminary bioassays indicated that all the analogues exhibited good insecticidal activities against Nilaparvata legen and Aphis medicagini at 500 mg L-1.
Nitromethylene neonicotinoids analogues with tetrahydropyrimidine fixed cis-configuration: Synthesis, lnsecticidal activities, and molecular docking studies
Chuanwen, Sun,Dingrong, Yang,Jiahua, Xing,Haifeng, Wang,Jia, Jin,Jun, Zhu
experimental part, p. 3415 - 3421 (2011/07/30)
Two series of new nitromethylene neonicotinoid analogues (2a-2h and 3a-3h) were designed and prepared, with the cis-configuration confirmed by X-ray diffraction. Preliminary bioassays showed that most analogues exhibited excellent insectlcidal activities at 500 mg/L, and analogues with optical activity (2c-2g) were highly potent at 100 mg/L, while compound 2d had >90% mortality at 20 mg/L, which suggested that it could be used as a lead for future insecticides development. Modeling the ligand-receptor complexes by molecular docking study explained the structureactivity relationships observed in vitro and revealed an intriguing molecular binding mode at the active site of the nAChR model, thereby possibly providing some useful information for future receptor structure-based designs of novel insecticidal compounds.
