120573-32-2Relevant academic research and scientific papers
Studies in Antiparasitic Agents: Part 8 - Synthesis of 2-Substitutedamino-5(6)-benzoylbenzimidazoles as Structural Analogs of Mebendazole Metabolites
Singh, Sudhir K.,Naim, S. Shawkat,Sharma, Satyavan
, p. 1015 - 1018 (2007/10/02)
The synthesis of a series of 2-substitutedamino-5(6)-benzoylbenzimidazoles (6-22) has been carried out as the structural analogs of 2-amino-5(6)-benzoyl/α-hydroxy-α-phenylmethylbenzimidazoles (3, 4), the two metabolites of mebendazole.The compounds 6-22 have been tested for their anthelmintic activity against Ancylostoma ceylanicum, Nippostrongylus brasiliensis and Hymenolepis nana in rodents.Compounds 9, 11, 12, 13 and 14 exhibit 100percent elimination of A. ceylanicum worms from the animals at a single oral dose of 50-250 mg/kg.Some of the compounds also show activity against H. nana and N. brasiliensis.
