1206726-26-2Relevant articles and documents
Synthesis of novel PPARα/γ dual agonists as potential drugs for the treatment of the metabolic syndrome and diabetes type II designed using a new de novo design program PROTOBUILD
Bhurruth-Alcor, Yushma,Rost, Therese,Jorgensen, Michael R.,Kontogiorgis, Christos,Skorve, Jon,Cooper, Robert G.,Sheridan, Joseph M.,Hamilton, William D. O.,Heal, Jonathan R.,Berge, Rolf K.,Miller, Andrew D.
, p. 1169 - 1188 (2011/04/15)
Peroxisome proliferator activated receptors (PPARs) have been shown to have critical roles in fatty acid oxidation, triglyceride synthesis, and lipid metabolism - making them an important target in drug discovery. Here we describe the in silico design, sy
INDOLE COMPOUNDS
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Page/Page column 27-28, (2010/04/03)
Novel indole compounds which interact with peroxisome proliferator-activated receptors (PPARs) are disclosed. The compounds have an influence on metabolic diseases, obesity and diabetes.