385449-78-5

Upstream product

• 246219-81-8 methyl 2-(6-amino-5-iodopyridin-3-yl)-2-methylpropanoate 
• 246231-08-3 (S)-1-(2-azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-benzyloxy-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-1-(tert-butoxycarbonyl)pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one 
• 246231-09-4 (S)-1-(2-azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-hydroxy-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-1-(tert-butoxycarbonyl)-pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one 
• 246231-10-7 (S)-1-(2-Azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-amino-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-1-(tert-butoxycarbonyl)-pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one 
• 246231-07-2 (S)-1-(2-Azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-benzyloxy-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one 
• 246224-05-5 (S)-2-[3-(2-Benzyloxy-1-methylethyl)-2-(3,5-dimethyl-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-2-methylpropanoic acid 
• 246219-74-9 methyl (S)-2-[3-(2-benzyloxy-1-methylethyl)-2-triethylsilyl-1H-pyrrolo[2,3-b]pyridin-5-yl]-2-methylpropanoate 
• 246219-76-1 methyl (S)-2-[3-(2-benzyloxy-1-methylethyl)-2-(3,5-dimethyl-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-2-methylpropanoate 
• 246219-75-0 methyl (S)-2-[3-(2-benzyloxy-1-methylethyl)-2-iodo-1H-pyrrolo[2,3-b]pyridin-5-yl]-2-methylpropanoate 
• 246219-77-2 ethyl 2-[6-(2,2-dimethyl-4-oxo-4H-1,3-benzoxazin-3-yl)-pyridin-3-yl]-2-methylpropanoate 
• 385449-77-4 2-(6-amino-pyridin-3-yl)-2-methyl-propionic acid 
• 246219-79-4 2-(6-amino-pyridin-3-yl)-2-methyl-propionic acid methyl ester 
• 169253-21-8 2-methyl-2-(1-oxy-pyridin-3-yl)-propionic acid ethyl ester 
• 120690-70-2 ethyl 2-methyl-2-(pyridin-3-yl)propionate 

Relevant academic research and scientific papers

Total syntheses of 6- and 7-azaindole derived GnRH antagonists

The palladium(0)-catalyzed heteroannulation of a triethylsilyl alkyne and an ortho-aminoiodopyridine derivative is used as the key step in a highly convergent route to 6- and 7-azaindoles of biological interest.