385449-77-4

Basic information

• Product Name: 2-(6-aMinopyridin-3-yl)-2-Methylpropanoic acid
• Synonyms: 2-(6-aMinopyridin-3-yl)-2-Methylpropanoic acid;3-Pyridineacetic acid, 6-amino-α,α-dimethyl-
• CAS NO: 385449-77-4
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.20378
• Mol File: 385449-77-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(6-aMinopyridin-3-yl)-2-Methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-aMinopyridin-3-yl)-2-Methylpropanoic acid(385449-77-4)
• EPA Substance Registry System: 2-(6-aMinopyridin-3-yl)-2-Methylpropanoic acid(385449-77-4)

Safety Data

• Hazardous Substances Data: 385449-77-4(Hazardous Substances Data)

Usage

Molecular structure

Contains a pyridine ring and an amino group.

Derivative

Of nicotinic acid.

Function

Can act as a precursor in the biosynthesis of the coenzyme NAD+.

Therapeutic effects

Studied for its potential role in the treatment of neurodegenerative disorders, such as Alzheimer's disease.

Pharmaceutical development

Explored as a potential building block for the development of new pharmaceuticals.

Upstream product

• 246219-77-2 ethyl 2-[6-(2,2-dimethyl-4-oxo-4H-1,3-benzoxazin-3-yl)-pyridin-3-yl]-2-methylpropanoate 
• 444811-18-1 5-bromo-N,N-bis[(4-methoxyphenyl)methyl]pyridin-2-amine 
• 246219-79-4 2-(6-amino-pyridin-3-yl)-2-methyl-propionic acid methyl ester 
• 1319054-94-8 C₂₆H₃₀N₂O₄ 
• 1072-97-5 5-bromo-2-pyridylamine 
• 169253-21-8 2-methyl-2-(1-oxy-pyridin-3-yl)-propionic acid ethyl ester 
• 120690-70-2 ethyl 2-methyl-2-(pyridin-3-yl)propionate 

Downstream Products

• 246219-75-0 methyl (S)-2-[3-(2-benzyloxy-1-methylethyl)-2-iodo-1H-pyrrolo[2,3-b]pyridin-5-yl]-2-methylpropanoate 
• 246219-76-1 methyl (S)-2-[3-(2-benzyloxy-1-methylethyl)-2-(3,5-dimethyl-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-2-methylpropanoate 
• 246219-74-9 methyl (S)-2-[3-(2-benzyloxy-1-methylethyl)-2-triethylsilyl-1H-pyrrolo[2,3-b]pyridin-5-yl]-2-methylpropanoate 
• 246224-05-5 (S)-2-[3-(2-Benzyloxy-1-methylethyl)-2-(3,5-dimethyl-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-2-methylpropanoic acid 
• 246231-07-2 (S)-1-(2-Azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-benzyloxy-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one 
• 246231-10-7 (S)-1-(2-Azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-amino-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-1-(tert-butoxycarbonyl)-pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one 
• 246231-09-4 (S)-1-(2-azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-hydroxy-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-1-(tert-butoxycarbonyl)-pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one 
• 246231-08-3 (S)-1-(2-azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-benzyloxy-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-1-(tert-butoxycarbonyl)pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one 
• 385449-78-5 5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-3-[1-methyl-2-(2-pyridin-4-yl-ethylamino)-ethyl]-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester 
• 246219-79-4 2-(6-amino-pyridin-3-yl)-2-methyl-propionic acid methyl ester 

Relevant articles and documents

Synthesis of useful fragments in drug discovery: 2-Amino-5-tert- butylpyridine and its oxidised analogues

A novel and robust synthesis of the fragment, 2-amino-5-tert-butylpyridine, has been described, which has been shown to have improved physicochemical properties over 4-tert-butylaniline, when considering drug-like properties. The synthesis also yields fra

Total syntheses of 6- and 7-azaindole derived GnRH antagonists

The palladium(0)-catalyzed heteroannulation of a triethylsilyl alkyne and an ortho-aminoiodopyridine derivative is used as the key step in a highly convergent route to 6- and 7-azaindoles of biological interest.