120757-17-7

Basic information

• Product Name: methyl 3-(4-acetaminobenzoyl)butyrate
• Synonyms: methyl 3-(4-acetaminobenzoyl)butyrate
• CAS NO: 120757-17-7
• Molecular Weight: 263.293
• Mol File: 120757-17-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 3-(4-acetaminobenzoyl)butyrate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4-acetaminobenzoyl)butyrate(120757-17-7)
• EPA Substance Registry System: methyl 3-(4-acetaminobenzoyl)butyrate(120757-17-7)

Safety Data

• Hazardous Substances Data: 120757-17-7(Hazardous Substances Data)

Upstream product

• 82923-97-5 3-methoxycarbonyl-2-methyl-propionic acid chloride 
• 103-84-4 Acetanilid 
• 120757-14-4 3-(4-acetamidobenzoyl)-4-(N-piperidinyl)butanoic acid 
• 120757-15-5 4-(4-Amino-phenyl)-4-oxo-3-piperidin-1-ylmethyl-butyric acid methyl ester 
• 5473-15-4 4-(4-acetamidophenyl)-4-oxobutanoic acid 
• 52240-86-5 4-(4-Amino-phenyl)-3-methyl-4-oxo-butyric acid methyl ester 
• 108-24-7 acetic anhydride 
• 120757-16-6 3-(4-Acetylamino-benzoyl)-but-3-enoic acid methyl ester 
• 132298-10-3 N-[4-((R)-2-Chloro-propionyl)-phenyl]-acetamide 

Downstream Products

• 136609-85-3 6-(3,4-diaminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one 
• 118428-37-8 pimobendan 
• 36725-28-7 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone 
• 115344-47-3 2 cyano 1 methyl 3 [4 (4 methyl 6 oxo 1,4,5,6 tetrahydro 3 pyridazinyl)phenyl]guanidine 
• 99591-85-2 6-<4-(N'-cyano-S-methylisothioureido)phenyl>-5-methyl-4,5-dihydropyridazin-3(2H)-one 
• 112127-66-9 5-methyl-6-[4-(4-oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone 
• 36725-27-6 SKF 93741 

Relevant articles and documents

Chemical synthesis method of Pimobendan

The invention discloses a chemical synthesis method of Pimobendan. The method comprises steps as follows: acetanilide and 2-methyl-3-(chloroformyl)propionate react to produce 3-p-acetylaminobenzoyl methyl butyrate in a mixed organic solvent under the action of a composite catalyst, 3-p-acetylaminobenzoyl methyl butyrate reacts with a nitration reagent, 3-(4-acetamido-3-nitrobenzoyl)-methyl butyrate is produced and subjected to a reflux reaction with alkali in an alcohol solvent to produce 3-(4-amino-3-nitrobenzoyl) butyrate, 3-(4-amino-3-nitrobenzoyl) butyrate and hydrazine hydrate are subjected to a reflux reaction, 4,5-dihydro-5-methyl-6-(4-amino-3-nitrophenyl)-3(2H)-pyridazinone is produced and reduced with zinc powder in absolute methanol, 4,5-dihydro-5-methyl-6-(3,4-diaminophenyl)-3(2H)-pyridazinone is produced and subjected to a reflux reaction with p-anisaldehyde, and Pimobendan is obtained. The method comprises a few reaction steps, operation is safe and convenient, and the cost is low.

An Enantioselective Synthesis of SK and F 93505, a Key Intermediate for Preparing Cardiotonic Agents

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